Selective Cytotoxicity of 1,3,4-Thiadiazolium Mesoionic Derivatives on Hepatocarcinoma Cells (HepG2).

Selective Cytotoxicity of 1,3,4-Thiadiazolium Mesoionic Derivatives on Hepatocarcinoma Cells (HepG2).

In this work, we evaluated the cytotoxicity of mesoionic 4-phenyl-5-(2-Y, 4-X or 4-X-cinnamoyl)-1,3,4-thiadiazolium-2-phenylamine chloride derivatives (MI-J: X=OH, Y=H; MI-D: X=NO2, Y=H; MI-4F: X=F, Y=H; MI-2,4diF: X=Y=F) on human hepatocellular carcinoma (HepG2), and non-tumor cells (rat hepatocyte...

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Main Authors: Gustavo Jabor Gozzi, Amanda do Rocio Andrade Pires, Glaucio Valdameri, Maria Eliane Merlin Rocha, Glaucia Regina Martinez, Guilhermina Rodrigues Noleto, Alexandra Acco, Carlos Eduardo Alves de Souza, Aurea Echevarria, Camilla Moretto Dos Reis, Attilio Di Pietro, Sílvia Maria Suter Correia Cadena
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0130046

Internet

https://doi.org/10.1371/journal.pone.0130046

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