Male breast cancer: a clinicopathological study of an Egyptian population (Alexandria experience)
Aim of the study : The purpose of this retrospective study is to evaluate the clinicopathological features and treatment results of male breast cancer presented to our tertiary referral center. Material and methods : Between January 1998 and December 2005, a total of 39 men with breast cancer tre...
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doaj-59654ac9c3654c5bb1d3d117401fa5f22020-11-24T20:57:02ZengTermedia Publishing HouseContemporary Oncology1428-25261897-43092016-09-0120433534010.5114/wo.2016.6185528195Male breast cancer: a clinicopathological study of an Egyptian population (Alexandria experience)Maher SolimanMarcin HetnałAim of the study : The purpose of this retrospective study is to evaluate the clinicopathological features and treatment results of male breast cancer presented to our tertiary referral center. Material and methods : Between January 1998 and December 2005, a total of 39 men with breast cancer treated at Alexandria Main University Hospital and their medical records were reviewed. Results : The median age of patients was 59 years. Only 3 (7.7%) patients had positive family history. All patients presented by breast swellings that were associated with axillary mass in about one third of them. Around 80% had hormone receptor positive (estrogen and/or progesterone receptors). Two third of patients had advanced T-stage (T3 and T4). Left sided breast cancer occurred in 51.3%. Infiltrating ductal carcinoma was the most common type of histology encountered and grade 2 was the predominant grade of tumor. Modified radical mastectomy was the most common (87.2%) type of surgery done followed by chemotherapy for 32 patients and loco-regional radiotherapy for 20 patients. Tamoxifen was administered in 31 patients. Distant relapse occurred in 7 patients (17.9%) and local recurrence occurred in 2 patients (5.1%). The 5-year disease-free survival (DFS) was 82% and the 5-year overall survival (OS) rate was 84%. Only negative axillary lymph node and positive hormone receptor status were significantly associated with favorable DFS and OS. T-stage, grade of tumor and type of chemotherapy given had no statistically significant impact on either DFS or OS. Conclusions : Male breast cancer is still under-investigated and further researches are warranted.https://www.termedia.pl/Male-breast-cancer-a-clinicopathological-study-of-an-Egyptian-population-Alexandria-experience-,3,28195,1,1.htmlbreast cancer male |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maher Soliman Marcin Hetnał |
spellingShingle |
Maher Soliman Marcin Hetnał Male breast cancer: a clinicopathological study of an Egyptian population (Alexandria experience) Contemporary Oncology breast cancer male |
author_facet |
Maher Soliman Marcin Hetnał |
author_sort |
Maher Soliman |
title |
Male breast cancer: a clinicopathological study of an Egyptian population (Alexandria experience) |
title_short |
Male breast cancer: a clinicopathological study of an Egyptian population (Alexandria experience) |
title_full |
Male breast cancer: a clinicopathological study of an Egyptian population (Alexandria experience) |
title_fullStr |
Male breast cancer: a clinicopathological study of an Egyptian population (Alexandria experience) |
title_full_unstemmed |
Male breast cancer: a clinicopathological study of an Egyptian population (Alexandria experience) |
title_sort |
male breast cancer: a clinicopathological study of an egyptian population (alexandria experience) |
publisher |
Termedia Publishing House |
series |
Contemporary Oncology |
issn |
1428-2526 1897-4309 |
publishDate |
2016-09-01 |
description |
Aim of the study : The purpose of this retrospective study is to evaluate the clinicopathological features and treatment results of male breast cancer presented to our tertiary referral center.
Material and methods : Between January 1998 and December 2005, a total of 39 men with breast cancer treated at Alexandria Main University Hospital and their medical records were reviewed.
Results : The median age of patients was 59 years. Only 3 (7.7%) patients had positive family history. All patients presented by breast swellings that were associated with axillary mass in about one third of them. Around 80% had hormone receptor positive (estrogen and/or progesterone receptors). Two third of patients had advanced T-stage (T3 and T4). Left sided breast cancer occurred in 51.3%. Infiltrating ductal carcinoma was the most common type of histology encountered and grade 2 was the predominant grade of tumor. Modified radical mastectomy was the most common (87.2%) type of surgery done followed by chemotherapy for 32 patients and loco-regional radiotherapy for 20 patients. Tamoxifen was administered in 31 patients. Distant relapse occurred in 7 patients (17.9%) and local recurrence occurred in 2 patients (5.1%). The 5-year disease-free survival (DFS) was 82% and the 5-year overall survival (OS) rate was 84%. Only negative axillary lymph node and positive hormone receptor status were significantly associated with favorable DFS and OS. T-stage, grade of tumor and type of chemotherapy given had no statistically significant impact on either DFS or OS.
Conclusions : Male breast cancer is still under-investigated and further researches are warranted. |
topic |
breast cancer male |
url |
https://www.termedia.pl/Male-breast-cancer-a-clinicopathological-study-of-an-Egyptian-population-Alexandria-experience-,3,28195,1,1.html |
work_keys_str_mv |
AT mahersoliman malebreastcanceraclinicopathologicalstudyofanegyptianpopulationalexandriaexperience AT marcinhetnał malebreastcanceraclinicopathologicalstudyofanegyptianpopulationalexandriaexperience |
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1716788940048957440 |