EVALUATION OF LIPID AND LIPOPROTEIN PROFILE IN PATIENTS WITH TYPE 2 DIABETES
ABSTRACT Objective: To evaluate the pattern of lipid and lipoprotein profile in patients with type 2 diabetes (T2D). Methods: In this prospective study, which was carried out in Basrah, Southern Iraq, serum concentrations of glucose “fasting blood sugar” (FBS), total cholesterol (TC), high density l...
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doaj-59787101f8ac4eaab23ae573f709ee5e2020-11-25T03:13:33ZengUniversity of BasrahThe Medical Journal of Basrah University 0253-07592413-44142010-06-01281273210.33762/mjbu.2010.4945849458EVALUATION OF LIPID AND LIPOPROTEIN PROFILE IN PATIENTS WITH TYPE 2 DIABETESLamia M. Al-NaamaSalman K. AjlanMariam S. MahmoodABSTRACT Objective: To evaluate the pattern of lipid and lipoprotein profile in patients with type 2 diabetes (T2D). Methods: In this prospective study, which was carried out in Basrah, Southern Iraq, serum concentrations of glucose “fasting blood sugar” (FBS), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), triglycerides (TG) and very low density lipoprotein-cholesterol (VLDL-C) were measured in 92 patients (43 males and 49 females) with T2D and 120 control subjects (35 males and 85 females). Results: Patients with T2D have significantly higher serum concentrations of TC, LDL-C, TG, VLDL-C and LDLC/ HDL-C ratio (P<0.001) and significantly lower HDL-C serum concentration (P<0.001) compared to control subjects. Male patients with T2D showed significantly higher TC, LDL-C serum concentrations and LDL-C/HDL-C ratio in comparison to control subjects (P<0.001), while serum HDL-C concentration was significantly lower among T2D patients compared to controls (P<0.001). No significant differences were seen in serum TG and VLDL-C concentrations between male patients and control subjects (P>0.05). In females, serum levels of TC, LDL-C, TG, VLDL-C, and LDL-C/ HDL-C ratio were significantly higher (P<0.001), and serum HDL-C level was significantly lower (P<0.05) in patients with T2D than in control subjects. Conclusion: T2D has marked effects on lipid and lipoprotein profile causing a diversity of dyslipidaemia, that might lead to atherosclerosis, and hence, increasing the risk of coronary heart disease.https://mjbu.uobasrah.edu.iq/article_49458_a6279155d676073831c6f7cf374950f4.pdf |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lamia M. Al-Naama Salman K. Ajlan Mariam S. Mahmood |
spellingShingle |
Lamia M. Al-Naama Salman K. Ajlan Mariam S. Mahmood EVALUATION OF LIPID AND LIPOPROTEIN PROFILE IN PATIENTS WITH TYPE 2 DIABETES The Medical Journal of Basrah University |
author_facet |
Lamia M. Al-Naama Salman K. Ajlan Mariam S. Mahmood |
author_sort |
Lamia M. Al-Naama |
title |
EVALUATION OF LIPID AND LIPOPROTEIN PROFILE IN PATIENTS WITH TYPE 2 DIABETES |
title_short |
EVALUATION OF LIPID AND LIPOPROTEIN PROFILE IN PATIENTS WITH TYPE 2 DIABETES |
title_full |
EVALUATION OF LIPID AND LIPOPROTEIN PROFILE IN PATIENTS WITH TYPE 2 DIABETES |
title_fullStr |
EVALUATION OF LIPID AND LIPOPROTEIN PROFILE IN PATIENTS WITH TYPE 2 DIABETES |
title_full_unstemmed |
EVALUATION OF LIPID AND LIPOPROTEIN PROFILE IN PATIENTS WITH TYPE 2 DIABETES |
title_sort |
evaluation of lipid and lipoprotein profile in patients with type 2 diabetes |
publisher |
University of Basrah |
series |
The Medical Journal of Basrah University |
issn |
0253-0759 2413-4414 |
publishDate |
2010-06-01 |
description |
ABSTRACT
Objective: To evaluate the pattern of lipid and lipoprotein profile in patients with type 2 diabetes (T2D).
Methods: In this prospective study, which was carried out in Basrah, Southern Iraq, serum concentrations of glucose
“fasting blood sugar” (FBS), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density
lipoprotein-cholesterol (LDL-C), triglycerides (TG) and very low density lipoprotein-cholesterol (VLDL-C) were
measured in 92 patients (43 males and 49 females) with T2D and 120 control subjects (35 males and 85 females).
Results: Patients with T2D have significantly higher serum concentrations of TC, LDL-C, TG, VLDL-C and LDLC/
HDL-C ratio (P<0.001) and significantly lower HDL-C serum concentration (P<0.001) compared to control
subjects. Male patients with T2D showed significantly higher TC, LDL-C serum concentrations and LDL-C/HDL-C
ratio in comparison to control subjects (P<0.001), while serum HDL-C concentration was significantly lower among
T2D patients compared to controls (P<0.001). No significant differences were seen in serum TG and VLDL-C
concentrations between male patients and control subjects (P>0.05). In females, serum levels of TC, LDL-C, TG,
VLDL-C, and LDL-C/ HDL-C ratio were significantly higher (P<0.001), and serum HDL-C level was significantly
lower (P<0.05) in patients with T2D than in control subjects.
Conclusion: T2D has marked effects on lipid and lipoprotein profile causing a diversity of dyslipidaemia, that
might lead to atherosclerosis, and hence, increasing the risk of coronary heart disease. |
url |
https://mjbu.uobasrah.edu.iq/article_49458_a6279155d676073831c6f7cf374950f4.pdf |
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