"Transformation of chronic myelogenous leukemia to Multiple Myeloma: A case report "

• Main Authors: "Ghavamzadeh A, Alimoghaddam K, Mehdipour P, Sharifian R, Schwanitz G, Shamshiri AR "
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2003-05-01
• Series: Acta Medica Iranica
• Subjects: Myeloid; Chronic; Cell transformation; Neoplastic; Philadelphia chromosome
• Online Access: http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/1037.pdf&manuscript_id=1037

Chronic myelogenous leukemia (CML) is a stem cell disorder sometimes associated with lymphoproliferative disorders. CML may precede a lymphoproliferative disorder. There are a few reports showing associating of CML with multiple myeloma and we report a known CML case that transformed into a full-blown multiple myeloma. This patient had more than 69% of infiltrating myeloma cells in her bone marrow and Philadelphia chromosome was detected in 18 out of 42. However, the probable presence of some myeloma cells with classic Philadelphia-positive chromosome could be proposed.