Low Affinity DnaA-ATP Recognition Sites in E. coli oriC Make Non-equivalent and Growth Rate-Dependent Contributions to the Regulated Timing of Chromosome Replication

Low Affinity DnaA-ATP Recognition Sites in E. coli oriC Make Non-equivalent and Growth Rate-Dependent Contributions to the Regulated Timing of Chromosome Replication

Although the mechanisms that precisely time initiation of chromosome replication in bacteria remain unclear, most clock models are based on accumulation of the active initiator protein, DnaA-ATP. During each cell division cycle, sufficient DnaA-ATP must become available to interact with a distinct s...

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Bibliographic Details
Main Authors: Prassanna Rao, Tania A. Rozgaja, Abdulaziz Alqahtani, Julia E. Grimwade, Alan C. Leonard
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
oriC
DnaA
DNA replication
replication origin
orisomes
pre-replicative complexes
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01673/full

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https://www.frontiersin.org/article/10.3389/fmicb.2018.01673/full

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