Flexible RSV Prefusogenic Fusion Glycoprotein Exposes Multiple Neutralizing Epitopes that May Collectively Contribute to Protective Immunity

Flexible RSV Prefusogenic Fusion Glycoprotein Exposes Multiple Neutralizing Epitopes that May Collectively Contribute to Protective Immunity

Human respiratory syncytial virus (RSV) is a cause of lower respiratory tract infection in infants, young children, and older adults. There is no licensed vaccine and prophylactic treatment options are limited. The RSV fusion (F) glycoprotein is a target of host immunity and thus a focus for vaccine...

Full description

Bibliographic Details
Main Authors:	Nita Patel, Jing-Hui Tian, Rhonda Flores, Kelsey Jacobson, Michelle Walker, Alyse Portnoff, Mimi Gueber-Xabier, Michael J. Massare, Greg Glenn, Larry Ellingsworth, Gale Smith
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	Vaccines
Subjects:	respiratory syncytial virus fusion glycoprotein prefusogenic RSV F cotton rat
Online Access:	https://www.mdpi.com/2076-393X/8/4/607

Similar Items

Respiratory Syncytial Virus (RSV) G Protein Vaccines With Central Conserved Domain Mutations Induce CX3C-CX3CR1 Blocking Antibodies
by: Harrison C. Bergeron, et al.
Published: (2021-02-01)

Sublingual Immunization With an RSV G Glycoprotein Fragment Primes IL-17-Mediated Immunopathology Upon Respiratory Syncytial Virus Infection
by: In Su Cheon, et al.
Published: (2019-03-01)

Generation of recombinant human respiratory syncytial viruses to study antigenic subtype differences, attachment glycoprotein evolution, and polymerase localization
by: Olinger, Grace Y.
Published: (2018)

Features of the Human Antibody Response against the Respiratory Syncytial Virus Surface Glycoprotein G
by: Kristina Borochova, et al.
Published: (2020-06-01)

Chimeric Measles Virus (MV/RSV), Having Ectodomains of Respiratory Syncytial Virus (RSV) F and G Proteins Instead of Measles Envelope Proteins, Induced Protective Antibodies against RSV
by: Akihito Sawada, et al.
Published: (2021-02-01)

Current Insights Into Host Immune Responses to Human Respiratory Syncytial Virus (RSV) and Challenges Towards Efficient Treatments and Vaccines Against RSV
Published: (2020)

A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences
by: Mansi C. Pandya, et al.
Published: (2019-05-01)

Identification and Characterization of Essential Residues at the Apex of the RSV FusionProtein
by: Hicks, Stephanie
Published: (2018)

Humoral and Mucosal Antibody Response to RSV Structural Proteins in RSV-Infected Adult Hematopoietic Cell Transplant (HCT) Recipients
by: Xunyan Ye, et al.
Published: (2021-05-01)

Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine Development
by: Seyhan Boyoglu-Barnum, et al.
Published: (2019-07-01)

RSV Vaccine Based on Rhabdoviral Vector Protects after Single Immunization
by: Sarah Wilmschen, et al.
Published: (2019-07-01)

Epidemiology and prevention of respiratory syncytial virus infections in children in Italy
by: Chiara Azzari, et al.
Published: (2021-10-01)

Subversion of Host Cell Mitochondria by RSV to Favor Virus Production is Dependent on Inhibition of Mitochondrial Complex I and ROS Generation
by: MengJie Hu, et al.
Published: (2019-11-01)

The azithromycin to prevent wheezing following severe RSV bronchiolitis-II clinical trial: Rationale, study design, methods, and characteristics of study population
by: Mythili Srinivasan, et al.
Published: (2021-06-01)

Selective Blockade of TNFR1 Improves Clinical Disease and Bronchoconstriction in Experimental RSV Infection
by: Dorothea R. Morris, et al.
Published: (2020-10-01)

Mutation of Respiratory Syncytial Virus G Protein’s CX3C Motif Attenuates Infection in Cotton Rats and Primary Human Airway Epithelial Cells
by: Binh Ha, et al.
Published: (2019-07-01)

Fulminant ecchymosis as the initial manifestation of antiphospholipid syndrome (APS) triggered by respiratory syncytial virus (RSV) infection: A case report and review of the literature
by: Jun Makino, et al.
Published: (2017-01-01)

Two RSV Platforms for G, F, or G+F Proteins VLPs
by: Binh Ha, et al.
Published: (2020-08-01)

Perinatal Lamb Model of Respiratory Syncytial Virus (RSV) Infection
by: Mark R. Ackermann, et al.
Published: (2012-10-01)

Respiratory syncytial virus (RSV) bronchiolitis: comparative study of RSV groups A and B infected children
by: Selir M. Straliotto, et al.
Published: (1994-03-01)

Palivizumab e virus respiratorio sinciziale: una panoramica
by: Paolo Manzoni
Published: (2011-07-01)

The Central Conserved Region (CCR) of Respiratory Syncytial Virus (RSV) G Protein Modulates Host miRNA Expression and Alters the Cellular Response to Infection
by: Abhijeet A. Bakre, et al.
Published: (2017-07-01)

Dominance of the ON1 Genotype of RSV-A and BA9 Genotype of RSV-B in Respiratory Cases from Jeddah, Saudi Arabia
by: Hessa A. Al-Sharif, et al.
Published: (2020-11-01)

SOFIA®RSV: prospective laboratory evaluation and implementation of a rapid diagnostic test in a pediatric emergency ward
by: Léa C. Tran, et al.
Published: (2017-06-01)

RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection
by: Daniela Machado, et al.
Published: (2017-12-01)

Antibody Epitopes of Pneumovirus Fusion Proteins
by: Jiachen Huang, et al.
Published: (2019-11-01)

RSV Fusion: Time for a New Model
by: Richard G. Hegele, et al.
Published: (2013-03-01)

Layer-By-Layer Nanoparticle Vaccines Carrying the G Protein CX3C Motif Protect against RSV Infection and Disease
by: Patricia A. Jorquera, et al.
Published: (2015-10-01)

Morbidity and mortality of respiratory syncytial virus infection in hospitalized adults: Comparison with seasonal influenza
by: Alaa Atamna, et al.
Published: (2021-02-01)

A Meta-Analysis of Multiple Whole Blood Gene Expression Data Unveils a Diagnostic Host-Response Transcript Signature for Respiratory Syncytial Virus
by: Ruth Barral-Arca, et al.
Published: (2020-03-01)

Intervention Strategies for Seasonal and Emerging Respiratory Viruses with Drugs and Vaccines Targeting Viral Surface Glycoproteins
by: Ralph A. Tripp, et al.
Published: (2021-04-01)

Neonatal Genetic Delivery of Anti-Respiratory Syncytial Virus (RSV) Antibody by Non-Human Primate-Based Adenoviral Vector to Provide Protection against RSV
by: Rika Gomi, et al.
Published: (2018-12-01)

Predictors and incidence of hospitalization due to respiratory syncytial virus (RSV)-associated lower respiratory tract infection (LRTI) in non-prophylaxed moderate-to-late preterm infants in Bosnia and Herzegovina
by: Hajrija Maksić, et al.
Published: (2018-08-01)

A Case of Athabaskan Brainstem Dysgenesis Syndrome and RSV Respiratory Failure
by: Ellsworth T, et al.
Published: (2020-11-01)

Maternal Effects of Respiratory Syncytial Virus Infection during Pregnancy
by: Sarahn M. Wheeler, et al.
Published: (2015-11-01)

Bimodal Effects of Obesity Ratio on Disease Duration of Respiratory Syncytial Virus Infection in Children
by: Naoe Akiyama, et al.
Published: (2011-01-01)

A Respiratory Syncytial Virus Replicon That Is Non-Cytotoxic and Capable of Long-Term Foreign Gene Expression
by: Malykhina, Olga
Published: (2011)

Estudo de potenciais inibidores de inibidores de infecção causada por Vírus Sincicial Respiratório em cultura de célula
by: Rubio, Marcelo Luiz [UNESP]
Published: (2014)

Towards Better Understanding of Respiratory Syncytial Virus (RSV) Vaccine-Induced Enhanced Disease
by: Muralidharan, Abenaya
Published: (2019)

Respiratory syncytial virus (RSV) disease – new data needed to guide future policy
by: Louis Bont, et al.
Published: (2015-12-01)

Cannot write session to /tmp/vufind_sessions/sess_43o74k9j4g8thrim5be9rglpcu