Models of SIV rebound after treatment interruption that involve multiple reactivation events.
In order to assess the efficacy of novel HIV-1 treatments leading to a functional cure, the time to viral rebound is frequently used as a surrogate endpoint. The longer the time to viral rebound, the more efficacious the therapy. In support of such an approach, mathematical models serve as a connect...
Main Authors: | Christiaan H van Dorp, Jessica M Conway, Dan H Barouch, James B Whitney, Alan S Perelson |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-10-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1008241 |
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