Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

Inhibitors of the BET family proteins are limited by their potency and oral bio-availability. Here, the authors report a new BET inhibitor, NHWD-870, with improved potency compared to previous BET inhibitors, and show that it suppresses BRD4 and targets tumour associated macrophages.

Bibliographic Details
Main Authors:	Mingzhu Yin, Ying Guo, Rui Hu, Wesley L. Cai, Yao Li, Shiyao Pei, Hongyin Sun, Cong Peng, Jiali Li, Rui Ye, Qiaohong Yang, Nenghui Wang, Yongguang Tao, Xiang Chen, Qin Yan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15290-0

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record_format	Article
spelling	doaj-59a306de0a994d95ae774f48771aeb952021-05-11T08:59:23ZengNature Publishing GroupNature Communications2041-17232020-04-0111111410.1038/s41467-020-15290-0Potent BRD4 inhibitor suppresses cancer cell-macrophage interactionMingzhu Yin0Ying Guo1Rui Hu2Wesley L. Cai3Yao Li4Shiyao Pei5Hongyin Sun6Cong Peng7Jiali Li8Rui Ye9Qiaohong Yang10Nenghui Wang11Yongguang Tao12Xiang Chen13Qin Yan14Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Pathology, Yale School of MedicineDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Pathology, Yale School of MedicineDepartment of Pathology, Yale School of MedicineSchool of Basic Medical Sciences, Guangzhou University of Chinese MedicineNingbo Wenda Pharma, NinghaiKey Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Pathology, Yale School of MedicineInhibitors of the BET family proteins are limited by their potency and oral bio-availability. Here, the authors report a new BET inhibitor, NHWD-870, with improved potency compared to previous BET inhibitors, and show that it suppresses BRD4 and targets tumour associated macrophages.https://doi.org/10.1038/s41467-020-15290-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mingzhu Yin Ying Guo Rui Hu Wesley L. Cai Yao Li Shiyao Pei Hongyin Sun Cong Peng Jiali Li Rui Ye Qiaohong Yang Nenghui Wang Yongguang Tao Xiang Chen Qin Yan
spellingShingle	Mingzhu Yin Ying Guo Rui Hu Wesley L. Cai Yao Li Shiyao Pei Hongyin Sun Cong Peng Jiali Li Rui Ye Qiaohong Yang Nenghui Wang Yongguang Tao Xiang Chen Qin Yan Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction Nature Communications
author_facet	Mingzhu Yin Ying Guo Rui Hu Wesley L. Cai Yao Li Shiyao Pei Hongyin Sun Cong Peng Jiali Li Rui Ye Qiaohong Yang Nenghui Wang Yongguang Tao Xiang Chen Qin Yan
author_sort	Mingzhu Yin
title	Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
title_short	Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
title_full	Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
title_fullStr	Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
title_full_unstemmed	Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
title_sort	potent brd4 inhibitor suppresses cancer cell-macrophage interaction
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-04-01
description	Inhibitors of the BET family proteins are limited by their potency and oral bio-availability. Here, the authors report a new BET inhibitor, NHWD-870, with improved potency compared to previous BET inhibitors, and show that it suppresses BRD4 and targets tumour associated macrophages.
url	https://doi.org/10.1038/s41467-020-15290-0
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Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

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