Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections
Summary: Gut microbiota composition is associated with human and rodent Plasmodium infections, yet the mechanism by which gut microbiota affects the severity of malaria remains unknown. Humoral immunity is critical in mediating the clearance of Plasmodium blood stage infections, prompting the hypoth...
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doaj-59a4c8d52da148f2818ecae3666735b32020-12-17T04:48:01ZengElsevierCell Reports2211-12472020-12-013311108503Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium InfectionsMorgan L. Waide0Rafael Polidoro1Whitney L. Powell2Joshua E. Denny3Justin Kos4David A. Tieri5Corey T. Watson6Nathan W. Schmidt7Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA; Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USARyan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USADepartment of Microbiology and Immunology, University of Louisville, Louisville, KY, USADepartment of Microbiology and Immunology, University of Louisville, Louisville, KY, USADepartment of Biochemistry, University of Louisville, Louisville, KY, USADepartment of Biochemistry, University of Louisville, Louisville, KY, USADepartment of Biochemistry, University of Louisville, Louisville, KY, USADepartment of Microbiology and Immunology, University of Louisville, Louisville, KY, USA; Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA; Corresponding authorSummary: Gut microbiota composition is associated with human and rodent Plasmodium infections, yet the mechanism by which gut microbiota affects the severity of malaria remains unknown. Humoral immunity is critical in mediating the clearance of Plasmodium blood stage infections, prompting the hypothesis that mice with gut microbiota-dependent decreases in parasite burden exhibit better germinal center (GC) responses. In support of this hypothesis, mice with a low parasite burden exhibit increases in GC B cell numbers and parasite-specific antibody titers, as well as better maintenance of GC structures and a more targeted, qualitatively different antibody response. This enhanced humoral immunity affects memory, as mice with a low parasite burden exhibit robust protection against challenge with a heterologous, lethal Plasmodium species. These results demonstrate that gut microbiota composition influences the biology of spleen GCs as well as the titer and repertoire of parasite-specific antibodies, identifying potential approaches to develop optimal treatments for malaria.http://www.sciencedirect.com/science/article/pii/S2211124720314923malariaplasmodiummicrobiotagerminal centerantibodyimmune memory |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Morgan L. Waide Rafael Polidoro Whitney L. Powell Joshua E. Denny Justin Kos David A. Tieri Corey T. Watson Nathan W. Schmidt |
spellingShingle |
Morgan L. Waide Rafael Polidoro Whitney L. Powell Joshua E. Denny Justin Kos David A. Tieri Corey T. Watson Nathan W. Schmidt Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections Cell Reports malaria plasmodium microbiota germinal center antibody immune memory |
author_facet |
Morgan L. Waide Rafael Polidoro Whitney L. Powell Joshua E. Denny Justin Kos David A. Tieri Corey T. Watson Nathan W. Schmidt |
author_sort |
Morgan L. Waide |
title |
Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections |
title_short |
Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections |
title_full |
Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections |
title_fullStr |
Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections |
title_full_unstemmed |
Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections |
title_sort |
gut microbiota composition modulates the magnitude and quality of germinal centers during plasmodium infections |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2020-12-01 |
description |
Summary: Gut microbiota composition is associated with human and rodent Plasmodium infections, yet the mechanism by which gut microbiota affects the severity of malaria remains unknown. Humoral immunity is critical in mediating the clearance of Plasmodium blood stage infections, prompting the hypothesis that mice with gut microbiota-dependent decreases in parasite burden exhibit better germinal center (GC) responses. In support of this hypothesis, mice with a low parasite burden exhibit increases in GC B cell numbers and parasite-specific antibody titers, as well as better maintenance of GC structures and a more targeted, qualitatively different antibody response. This enhanced humoral immunity affects memory, as mice with a low parasite burden exhibit robust protection against challenge with a heterologous, lethal Plasmodium species. These results demonstrate that gut microbiota composition influences the biology of spleen GCs as well as the titer and repertoire of parasite-specific antibodies, identifying potential approaches to develop optimal treatments for malaria. |
topic |
malaria plasmodium microbiota germinal center antibody immune memory |
url |
http://www.sciencedirect.com/science/article/pii/S2211124720314923 |
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