Advantages of ketamine as a perioperative analgesic
The pharmacological effects of ketamine are being discovered constantly, and new mechanisms involving epi-genetics could account for some of its clinical responses. Nowadays, it is regarded as a pharmacological tool in translational research and has the potential to revolutionise the therapy of comp...
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doaj-59a5119e1fc04601a407ea11fe6334062020-11-25T00:46:34ZengPermanyerRevista Médica del Hospital General de México0185-10632018-10-01814253261Advantages of ketamine as a perioperative analgesicD.M. Rascón-Martínez0O. Carrillo-Torres1R.G. Ramos-Nataren2L. Rendón-Jaramillo3Anaesthesiology Department, UMAE Hospital de Especialidades CMN SIGLO XXI, Instituto Mexicano del Seguro Social, Mexico City, MexicoAnaesthesiologist and Intensivist Pain Manager at the Anaesthesiology Department of the Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, Mexico; Corresponding author at: Jardín 12 Belisario Domínguez sección XVI, Tlalpan, Mexico City, Mexico. Tel.: +52 5524422026.Anaesthesiologist at the Anaesthesiology Department, UMAE Hospital de Especialidades CMN SIGLO XXI, Instituto Mexicano del Seguro Social, Mexico City, MexicoAnaesthesiology Intern at the Anaesthesiology Department of the Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoThe pharmacological effects of ketamine are being discovered constantly, and new mechanisms involving epi-genetics could account for some of its clinical responses. Nowadays, it is regarded as a pharmacological tool in translational research and has the potential to revolutionise the therapy of complex patient conditions such as pain and depression.Medical interest in exploring the drug's properties has grown, as is demonstrated by the increased investigation over the last five years, according to research sites such as Pubmed. These publications draw attention to the multifaceted roles of ketamine as an anaesthetic, analgesic (in multiple contexts, chronic, acute, refractory and breakthrough pain), antihyperalgesic, neuromodulator, bronchodilator and/or antidepressant. It is therefore important to review the pharmacological characteristics and their implications in current treatments. Resumen: Los efectos farmacológicos de la ketamina están siendo continuamente descubiertos y nuevos mecanismos que involucran a la epi-genética podrían explicar algunas de sus respuestas clínicas. Hoy día se considera una herramienta farmacológica en la investigación translacional y tiene el potencial de revolucionar la terapéutica de condiciones complejas para el paciente como son el dolor y la depresión.El interés médico en conocer las propiedades del fármaco en diferentes contextos ha aumentado y prueba de ello es que en los últimos cinco años, ha habido un aumento significativo en la investigación según sitios como Pubmed. Estas publicaciones, muestran los roles multifacéticos de la ketamina como anestésico, analgésico (en múltiples contextos como dolor agudo, crónico, refractario e irruptivo), antihiperalgésico, neuromodulador, broncodilatador y/o antidepresivo. Por ello es importante revisar las características farmacológicas y sus implicaciones en la terapéutica actual. Keywords: Ketamine, Analgesia, Pain, Palabras clave: Ketamina, Analgesia, Dolorhttp://www.sciencedirect.com/science/article/pii/S0185106316301196 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
D.M. Rascón-Martínez O. Carrillo-Torres R.G. Ramos-Nataren L. Rendón-Jaramillo |
spellingShingle |
D.M. Rascón-Martínez O. Carrillo-Torres R.G. Ramos-Nataren L. Rendón-Jaramillo Advantages of ketamine as a perioperative analgesic Revista Médica del Hospital General de México |
author_facet |
D.M. Rascón-Martínez O. Carrillo-Torres R.G. Ramos-Nataren L. Rendón-Jaramillo |
author_sort |
D.M. Rascón-Martínez |
title |
Advantages of ketamine as a perioperative analgesic |
title_short |
Advantages of ketamine as a perioperative analgesic |
title_full |
Advantages of ketamine as a perioperative analgesic |
title_fullStr |
Advantages of ketamine as a perioperative analgesic |
title_full_unstemmed |
Advantages of ketamine as a perioperative analgesic |
title_sort |
advantages of ketamine as a perioperative analgesic |
publisher |
Permanyer |
series |
Revista Médica del Hospital General de México |
issn |
0185-1063 |
publishDate |
2018-10-01 |
description |
The pharmacological effects of ketamine are being discovered constantly, and new mechanisms involving epi-genetics could account for some of its clinical responses. Nowadays, it is regarded as a pharmacological tool in translational research and has the potential to revolutionise the therapy of complex patient conditions such as pain and depression.Medical interest in exploring the drug's properties has grown, as is demonstrated by the increased investigation over the last five years, according to research sites such as Pubmed. These publications draw attention to the multifaceted roles of ketamine as an anaesthetic, analgesic (in multiple contexts, chronic, acute, refractory and breakthrough pain), antihyperalgesic, neuromodulator, bronchodilator and/or antidepressant. It is therefore important to review the pharmacological characteristics and their implications in current treatments. Resumen: Los efectos farmacológicos de la ketamina están siendo continuamente descubiertos y nuevos mecanismos que involucran a la epi-genética podrían explicar algunas de sus respuestas clínicas. Hoy día se considera una herramienta farmacológica en la investigación translacional y tiene el potencial de revolucionar la terapéutica de condiciones complejas para el paciente como son el dolor y la depresión.El interés médico en conocer las propiedades del fármaco en diferentes contextos ha aumentado y prueba de ello es que en los últimos cinco años, ha habido un aumento significativo en la investigación según sitios como Pubmed. Estas publicaciones, muestran los roles multifacéticos de la ketamina como anestésico, analgésico (en múltiples contextos como dolor agudo, crónico, refractario e irruptivo), antihiperalgésico, neuromodulador, broncodilatador y/o antidepresivo. Por ello es importante revisar las características farmacológicas y sus implicaciones en la terapéutica actual. Keywords: Ketamine, Analgesia, Pain, Palabras clave: Ketamina, Analgesia, Dolor |
url |
http://www.sciencedirect.com/science/article/pii/S0185106316301196 |
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