Effects of <i>Lactobacillus plantarum</i> PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial
This four-week, randomized, double-blind, placebo-controlled study investigated the effects of <i>Lactobacillus plantarum</i> PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7–15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Au...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-04-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/11/4/820 |
id |
doaj-59a58a2890f2492a8bf9e8374c3e062e |
---|---|
record_format |
Article |
spelling |
doaj-59a58a2890f2492a8bf9e8374c3e062e2020-11-25T00:06:36ZengMDPI AGNutrients2072-66432019-04-0111482010.3390/nu11040820nu11040820Effects of <i>Lactobacillus plantarum</i> PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled TrialYen-Wenn Liu0Min Tze Liong1Yu-Chu Ella Chung2Hui-Yi Huang3Wu-Shun Peng4Yun-Fang Cheng5Yu-Siou Lin6Yu-Yu Wu7Ying-Chieh Tsai8Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, TaiwanSchool of Industrial Technology, Universiti Sains Malaysia, Penang 11800, MalaysiaInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 10050, TaiwanDepartment of Psychology, National Taiwan University, Taipei 10090, TaiwanInstitute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, TaiwanInstitute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, TaiwanDepartment of Psychology, National Chengchi University, Taipei 11605, TaiwanYuNing Clinic, Taipei 10664, TaiwanInstitute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, TaiwanThis four-week, randomized, double-blind, placebo-controlled study investigated the effects of <i>Lactobacillus plantarum</i> PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7–15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 7−12) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms.https://www.mdpi.com/2072-6643/11/4/820autism spectrum disorder (ASD)psychobiotic<i>Lactobacillus plantarum</i> PS128hyperactivityanxiety |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yen-Wenn Liu Min Tze Liong Yu-Chu Ella Chung Hui-Yi Huang Wu-Shun Peng Yun-Fang Cheng Yu-Siou Lin Yu-Yu Wu Ying-Chieh Tsai |
spellingShingle |
Yen-Wenn Liu Min Tze Liong Yu-Chu Ella Chung Hui-Yi Huang Wu-Shun Peng Yun-Fang Cheng Yu-Siou Lin Yu-Yu Wu Ying-Chieh Tsai Effects of <i>Lactobacillus plantarum</i> PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial Nutrients autism spectrum disorder (ASD) psychobiotic <i>Lactobacillus plantarum</i> PS128 hyperactivity anxiety |
author_facet |
Yen-Wenn Liu Min Tze Liong Yu-Chu Ella Chung Hui-Yi Huang Wu-Shun Peng Yun-Fang Cheng Yu-Siou Lin Yu-Yu Wu Ying-Chieh Tsai |
author_sort |
Yen-Wenn Liu |
title |
Effects of <i>Lactobacillus plantarum</i> PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial |
title_short |
Effects of <i>Lactobacillus plantarum</i> PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial |
title_full |
Effects of <i>Lactobacillus plantarum</i> PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial |
title_fullStr |
Effects of <i>Lactobacillus plantarum</i> PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial |
title_full_unstemmed |
Effects of <i>Lactobacillus plantarum</i> PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial |
title_sort |
effects of <i>lactobacillus plantarum</i> ps128 on children with autism spectrum disorder in taiwan: a randomized, double-blind, placebo-controlled trial |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-04-01 |
description |
This four-week, randomized, double-blind, placebo-controlled study investigated the effects of <i>Lactobacillus plantarum</i> PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7–15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 7−12) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms. |
topic |
autism spectrum disorder (ASD) psychobiotic <i>Lactobacillus plantarum</i> PS128 hyperactivity anxiety |
url |
https://www.mdpi.com/2072-6643/11/4/820 |
work_keys_str_mv |
AT yenwennliu effectsofilactobacillusplantarumips128onchildrenwithautismspectrumdisorderintaiwanarandomizeddoubleblindplacebocontrolledtrial AT mintzeliong effectsofilactobacillusplantarumips128onchildrenwithautismspectrumdisorderintaiwanarandomizeddoubleblindplacebocontrolledtrial AT yuchuellachung effectsofilactobacillusplantarumips128onchildrenwithautismspectrumdisorderintaiwanarandomizeddoubleblindplacebocontrolledtrial AT huiyihuang effectsofilactobacillusplantarumips128onchildrenwithautismspectrumdisorderintaiwanarandomizeddoubleblindplacebocontrolledtrial AT wushunpeng effectsofilactobacillusplantarumips128onchildrenwithautismspectrumdisorderintaiwanarandomizeddoubleblindplacebocontrolledtrial AT yunfangcheng effectsofilactobacillusplantarumips128onchildrenwithautismspectrumdisorderintaiwanarandomizeddoubleblindplacebocontrolledtrial AT yusioulin effectsofilactobacillusplantarumips128onchildrenwithautismspectrumdisorderintaiwanarandomizeddoubleblindplacebocontrolledtrial AT yuyuwu effectsofilactobacillusplantarumips128onchildrenwithautismspectrumdisorderintaiwanarandomizeddoubleblindplacebocontrolledtrial AT yingchiehtsai effectsofilactobacillusplantarumips128onchildrenwithautismspectrumdisorderintaiwanarandomizeddoubleblindplacebocontrolledtrial |
_version_ |
1725421191249788928 |