Evidence Supporting Intralesional Stem Cell Therapy to Improve Equine Flexor Tendon Healing

<p><strong>Clinical bottom line</strong></p><p>Current experimental evidence suggests that intralesional stem cell administration improves the histological characteristics and matrix organisation of healing equine superficial digital flexor tendons (SDFT); however, the...

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Bibliographic Details
Main Authors: Sushmitha Durgam, Matthew Stewart
Format: Article
Language:English
Published: RCVS Knowledge 2017-01-01
Series:Veterinary Evidence
Subjects:
Online Access:https://veterinaryevidence.org/index.php/ve/article/view/50
Description
Summary:<p><strong>Clinical bottom line</strong></p><p>Current experimental evidence suggests that intralesional stem cell administration improves the histological characteristics and matrix organisation of healing equine superficial digital flexor tendons (SDFT); however, the clinical relevance of these findings are not clear. Current case-based evidence suggests that cell-based therapies improve the quality of tendon healing and reduce the recurrence rates of SDFT injuries but the lack of any randomised, controlled prospective studies with function-based outcomes is still concerning, given the widespread advocacy for and use of ‘stem cell’ therapies for the treatment of equine tendon injuries.</p><p> </p><img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />
ISSN:2396-9776