C-Reactive Protein: Clinical and Epidemiological Perspectives
An important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascul...
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doaj-59a69fa3d50148c0b2eefbc29b87fdc02020-11-24T23:16:38ZengHindawi LimitedCardiology Research and Practice2090-80162090-05972014-01-01201410.1155/2014/605810605810C-Reactive Protein: Clinical and Epidemiological PerspectivesJuan Salazar0María Sofía Martínez1Mervin Chávez2Alexandra Toledo3Roberto Añez4Yaquelín Torres5Vanessa Apruzzese6Carlos Silva7Joselyn Rojas8Valmore Bermúdez9Endocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, VenezuelaEndocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, VenezuelaEndocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, VenezuelaEndocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, VenezuelaEndocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, VenezuelaEndocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, VenezuelaEndocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, VenezuelaEndocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, VenezuelaEndocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, VenezuelaEndocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, VenezuelaAn important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascular risk in both primary and secondary prevention. C-reactive protein is a plasmatic protein of the pentraxin family and an acute phase reactant, very useful as a general inflammation marker. Currently, it is one of the most profoundly researched molecules in the cardiovascular field, yet its clinical applicability regarding cardiovascular risk remains an object of discussion, considered by some as a simple marker and by others as a true risk factor. In this sense, numerous studies propose its utilization as a predictor of cardiovascular risk through the use of high-sensitivity quantification methods for the detection of values <1 mg/L, following strict international guidelines. Increasing interest in these clinical findings has led to the creation of modified score systems including C-reactive protein concentrations, in order to enhance risk scores commonly used in clinical practice and offer improved care to patients with cardiovascular disease, which remains the first cause of mortality at the worldwide, national, and regional scenarios.http://dx.doi.org/10.1155/2014/605810 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juan Salazar María Sofía Martínez Mervin Chávez Alexandra Toledo Roberto Añez Yaquelín Torres Vanessa Apruzzese Carlos Silva Joselyn Rojas Valmore Bermúdez |
spellingShingle |
Juan Salazar María Sofía Martínez Mervin Chávez Alexandra Toledo Roberto Añez Yaquelín Torres Vanessa Apruzzese Carlos Silva Joselyn Rojas Valmore Bermúdez C-Reactive Protein: Clinical and Epidemiological Perspectives Cardiology Research and Practice |
author_facet |
Juan Salazar María Sofía Martínez Mervin Chávez Alexandra Toledo Roberto Añez Yaquelín Torres Vanessa Apruzzese Carlos Silva Joselyn Rojas Valmore Bermúdez |
author_sort |
Juan Salazar |
title |
C-Reactive Protein: Clinical and Epidemiological Perspectives |
title_short |
C-Reactive Protein: Clinical and Epidemiological Perspectives |
title_full |
C-Reactive Protein: Clinical and Epidemiological Perspectives |
title_fullStr |
C-Reactive Protein: Clinical and Epidemiological Perspectives |
title_full_unstemmed |
C-Reactive Protein: Clinical and Epidemiological Perspectives |
title_sort |
c-reactive protein: clinical and epidemiological perspectives |
publisher |
Hindawi Limited |
series |
Cardiology Research and Practice |
issn |
2090-8016 2090-0597 |
publishDate |
2014-01-01 |
description |
An important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascular risk in both primary and secondary prevention. C-reactive protein is a plasmatic protein of the pentraxin family and an acute phase reactant, very useful as a general inflammation marker. Currently, it is one of the most profoundly researched molecules in the cardiovascular field, yet its clinical applicability regarding cardiovascular risk remains an object of discussion, considered by some as a simple marker and by others as a true risk factor. In this sense, numerous studies propose its utilization as a predictor of cardiovascular risk through the use of high-sensitivity quantification methods for the detection of values <1 mg/L, following strict international guidelines. Increasing interest in these clinical findings has led to the creation of modified score systems including C-reactive protein concentrations, in order to enhance risk scores commonly used in clinical practice and offer improved care to patients with cardiovascular disease, which remains the first cause of mortality at the worldwide, national, and regional scenarios. |
url |
http://dx.doi.org/10.1155/2014/605810 |
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