Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case report

Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case report

High-grade squamous intraepithelial lesion of the vulva is a premalignant condition which may be especially resistant to treatments among immunosuppressed patients. We present our experience with the use of topical cidofovir in a refractory case of extensive vulvar high-grade squamous intraepithelia...

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Main Authors: Darosa Lim, Annie Belisle, Deana Funaro
Format: Article
Language:English
Published: SAGE Publishing 2020-02-01
Series:SAGE Open Medical Case Reports
Online Access:https://doi.org/10.1177/2050313X20904542
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spelling doaj-59b827a7d62243fbbfbccadc8953a78d2020-11-25T03:12:03ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2020-02-01810.1177/2050313X20904542Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case reportDarosa Lim0Annie Belisle1Deana Funaro2Division of Dermatology, Centre Hospitalier de l’Université de Montréal (CHUM), Montreal, QC, CanadaDepartment of Pathology, Centre Hospitalier de l’Université de Montréal (CHUM), Montreal, QC, CanadaDivision of Dermatology, Centre Hospitalier de l’Université de Montréal (CHUM), Montreal, QC, CanadaHigh-grade squamous intraepithelial lesion of the vulva is a premalignant condition which may be especially resistant to treatments among immunosuppressed patients. We present our experience with the use of topical cidofovir in a refractory case of extensive vulvar high-grade squamous intraepithelial lesion in a 37-year-old transplant patient. Eighteen cycles of cidofovir over a 2-year period led to a sustained significant improvement, mainly of the mucosal lesions and was well tolerated. To our knowledge, we have not seen this therapy described in transplant patients with extensive high-grade squamous intraepithelial lesion.https://doi.org/10.1177/2050313X20904542
collection DOAJ
language English
format Article
sources DOAJ
author Darosa Lim
Annie Belisle
Deana Funaro
spellingShingle Darosa Lim
Annie Belisle
Deana Funaro
Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case report
SAGE Open Medical Case Reports
author_facet Darosa Lim
Annie Belisle
Deana Funaro
author_sort Darosa Lim
title Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case report
title_short Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case report
title_full Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case report
title_fullStr Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case report
title_full_unstemmed Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case report
title_sort refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: a case report
publisher SAGE Publishing
series SAGE Open Medical Case Reports
issn 2050-313X
publishDate 2020-02-01
description High-grade squamous intraepithelial lesion of the vulva is a premalignant condition which may be especially resistant to treatments among immunosuppressed patients. We present our experience with the use of topical cidofovir in a refractory case of extensive vulvar high-grade squamous intraepithelial lesion in a 37-year-old transplant patient. Eighteen cycles of cidofovir over a 2-year period led to a sustained significant improvement, mainly of the mucosal lesions and was well tolerated. To our knowledge, we have not seen this therapy described in transplant patients with extensive high-grade squamous intraepithelial lesion.
url https://doi.org/10.1177/2050313X20904542
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AT anniebelisle refractoryextensivevulvarhighgradesquamousintraepitheliallesioninanimmunosuppressedtransplantpatienttreatedwithtopicalcidofoviracasereport
AT deanafunaro refractoryextensivevulvarhighgradesquamousintraepitheliallesioninanimmunosuppressedtransplantpatienttreatedwithtopicalcidofoviracasereport
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