Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells.

Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells.

The two T-box transcription factors T-bet and Eomesodermin (Eomes) are important regulators of cytotoxic lymphocytes (CTLs), such as activated CD8 T cells, which are essential in the fight against intracellular pathogens and tumors. Both transcription factors share a great degree of homology based o...

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Bibliographic Details
Main Authors: Jonas Fixemer, Jonas F Hummel, Frederic Arnold, Christoph S N Klose, Alexis Hofherr, Kristoffer Weissert, Tamara Kögl, Michael Köttgen, Sebastian J Arnold, Peter Aichele, Yakup Tanriver
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008870

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