Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs
Recent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy. Moreover, HCC onset and progression correlate with the deregulation of several long noncoding RNAs (lncRNAs), exhibiting great biological significanc...
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doaj-59c24ba7630b476e983b96a761698d542020-11-24T20:50:58ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/473942473942Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAsLaura Amicone0Franca Citarella1Carla Cicchini2Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyIstituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyRecent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy. Moreover, HCC onset and progression correlate with the deregulation of several long noncoding RNAs (lncRNAs), exhibiting great biological significance. As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms. Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development. The evidence presented in this review highlights that lncRNAs-mediated epigenetic regulation should be taken into account for potential targeted therapeutic approaches.http://dx.doi.org/10.1155/2015/473942 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura Amicone Franca Citarella Carla Cicchini |
spellingShingle |
Laura Amicone Franca Citarella Carla Cicchini Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs BioMed Research International |
author_facet |
Laura Amicone Franca Citarella Carla Cicchini |
author_sort |
Laura Amicone |
title |
Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs |
title_short |
Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs |
title_full |
Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs |
title_fullStr |
Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs |
title_full_unstemmed |
Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs |
title_sort |
epigenetic regulation in hepatocellular carcinoma requires long noncoding rnas |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Recent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy. Moreover, HCC onset and progression correlate with the deregulation of several long noncoding RNAs (lncRNAs), exhibiting great biological significance. As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms. Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development. The evidence presented in this review highlights that lncRNAs-mediated epigenetic regulation should be taken into account for potential targeted therapeutic approaches. |
url |
http://dx.doi.org/10.1155/2015/473942 |
work_keys_str_mv |
AT lauraamicone epigeneticregulationinhepatocellularcarcinomarequireslongnoncodingrnas AT francacitarella epigeneticregulationinhepatocellularcarcinomarequireslongnoncodingrnas AT carlacicchini epigeneticregulationinhepatocellularcarcinomarequireslongnoncodingrnas |
_version_ |
1716803117099515904 |