The State of the Nitric Oxide Cycle in Respiratory Tract Diseases
This review describes the unique links of the functioning of the nitric oxide cycle in the respiratory tract in normal and pathological conditions. The concept of a nitric oxide cycle has been expanded to include the NO-synthase and NO-synthase-independent component of its synthesis and the accompan...
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2020/4859260 |
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doaj-59e8816035bb4ed4a335d71ecdb2964f2020-11-25T03:59:43ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942020-01-01202010.1155/2020/48592604859260The State of the Nitric Oxide Cycle in Respiratory Tract DiseasesSvetlana Soodaeva0Igor Klimanov1Nailya Kubysheva2Nataliia Popova3Ildar Batyrshin4Pulmonology Scientific Research Institute under FMBA of Russia, Orekhovyy Bul’var 28, Moscow 115682, RussiaPulmonology Scientific Research Institute under FMBA of Russia, Orekhovyy Bul’var 28, Moscow 115682, RussiaKazan Federal University, 18 Kremlyovskaya St., Kazan 420000, RussiaPulmonology Scientific Research Institute under FMBA of Russia, Orekhovyy Bul’var 28, Moscow 115682, RussiaCentro de Investigación en Computación, Instituto Politécnico Nacional (CIC-IPN), Av. Juan de Dios Bátiz, Esq. Miguel Othón de Mendizábal S/N, Gustavo A. Madero, 07738 Mexico City, MexicoThis review describes the unique links of the functioning of the nitric oxide cycle in the respiratory tract in normal and pathological conditions. The concept of a nitric oxide cycle has been expanded to include the NO-synthase and NO-synthase-independent component of its synthesis and the accompanying redox cascades in varying degrees of reversible reactions. The role of non-NO-synthase cycle components has been shown. Detailed characteristics of substrates for the synthesis of nitric oxide (NO) in the human body, which can be nitrogen oxides, nitrite and nitrate anions, and organic nitrates, as well as nitrates and nitrites of food products, are given. The importance of the human microbiota in the nitric oxide cycle has been shown. The role of significant components of nitrite and nitrate reductase systems in the nitric oxide cycle and the mechanisms of their activation and deactivation (participation of enzymes, cofactors, homeostatic indicators, etc.) under various conditions have been determined. Consideration of these factors allows for a detailed understanding of the mechanisms underlying pathological conditions of the respiratory system and the targeting of therapeutic agents. The complexity of the NO cycle with multidirectional cascades could be best understood using dynamic modeling.http://dx.doi.org/10.1155/2020/4859260 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Svetlana Soodaeva Igor Klimanov Nailya Kubysheva Nataliia Popova Ildar Batyrshin |
spellingShingle |
Svetlana Soodaeva Igor Klimanov Nailya Kubysheva Nataliia Popova Ildar Batyrshin The State of the Nitric Oxide Cycle in Respiratory Tract Diseases Oxidative Medicine and Cellular Longevity |
author_facet |
Svetlana Soodaeva Igor Klimanov Nailya Kubysheva Nataliia Popova Ildar Batyrshin |
author_sort |
Svetlana Soodaeva |
title |
The State of the Nitric Oxide Cycle in Respiratory Tract Diseases |
title_short |
The State of the Nitric Oxide Cycle in Respiratory Tract Diseases |
title_full |
The State of the Nitric Oxide Cycle in Respiratory Tract Diseases |
title_fullStr |
The State of the Nitric Oxide Cycle in Respiratory Tract Diseases |
title_full_unstemmed |
The State of the Nitric Oxide Cycle in Respiratory Tract Diseases |
title_sort |
state of the nitric oxide cycle in respiratory tract diseases |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2020-01-01 |
description |
This review describes the unique links of the functioning of the nitric oxide cycle in the respiratory tract in normal and pathological conditions. The concept of a nitric oxide cycle has been expanded to include the NO-synthase and NO-synthase-independent component of its synthesis and the accompanying redox cascades in varying degrees of reversible reactions. The role of non-NO-synthase cycle components has been shown. Detailed characteristics of substrates for the synthesis of nitric oxide (NO) in the human body, which can be nitrogen oxides, nitrite and nitrate anions, and organic nitrates, as well as nitrates and nitrites of food products, are given. The importance of the human microbiota in the nitric oxide cycle has been shown. The role of significant components of nitrite and nitrate reductase systems in the nitric oxide cycle and the mechanisms of their activation and deactivation (participation of enzymes, cofactors, homeostatic indicators, etc.) under various conditions have been determined. Consideration of these factors allows for a detailed understanding of the mechanisms underlying pathological conditions of the respiratory system and the targeting of therapeutic agents. The complexity of the NO cycle with multidirectional cascades could be best understood using dynamic modeling. |
url |
http://dx.doi.org/10.1155/2020/4859260 |
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