Concentrations of serum VEGF and bFGF in Mongolia patients with diabetic retinopathy
AIM: To investigate the changes of serum angiogenic factors including vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in Mongolia patients with diabetic retinopathy(DR)and to explore their roles in the progress of DR. <p>METHODS: Eighty-three patients with diabe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2016-07-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2016/7/201607027.pdf |
| Summary: | AIM: To investigate the changes of serum angiogenic factors including vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in Mongolia patients with diabetic retinopathy(DR)and to explore their roles in the progress of DR. <p>METHODS: Eighty-three patients with diabetes were divided into three groups according to the retinopathy, no DR group(NDR, 25 cases), background DR(NPDR, 31 cases)and proliferative DR group(PDR, 27 cases), and 36 age-matched healthy people(control group)were selected. Serum concentrations of VEGF and bFGF were measured using ELISA method. <p>RESULTS:In Mongolia patients with diabetes, the serum concentrations of VEGF and bFGF were higher than those in control group; the serum concentrations of VEGF and bFGF in PDR group was higher than those of NDR and NPDR group(<i>P</i><0.05); the concentrations of VEGF and bFGF in NPDR group was higher than that of NDR group(<i>P</i><0.05).<p>CONCLUSION: High level of VEGF and bFGF may be the important pathogenic factors for DR in Mongolia patients. |
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| ISSN: | 1672-5123 1672-5123 |