Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles
Abstract Backgrounds Intolerable toxicity and unsatisfactory therapeutic effects are still big problems retarding the use of chemotherapy against cancer. Nano-drug delivery system promised a lot in increasing the patients’ compliance and therapeutic efficacy. As a unique nano-carrier, supermolecular...
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doaj-59ebe37db7624b2f850149d47079ff872020-11-25T03:23:02ZengBMCJournal of Nanobiotechnology1477-31552020-04-0118111210.1186/s12951-020-00612-7Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehiclesMing-yue Chen0Ze-kuan Xiao1Xue-ping Lei2Jie-xia Li3Xi-yong Yu4Jian-ye Zhang5Guo-dong Ye6Yu-juan Guo7Guangquan Mo8Chu-wen Li9Yu Zhang10Ling-min Zhang11Zhi-qiang Lin12Ji-jun Fu13The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityInstitute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science CenterThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical UniversityAbstract Backgrounds Intolerable toxicity and unsatisfactory therapeutic effects are still big problems retarding the use of chemotherapy against cancer. Nano-drug delivery system promised a lot in increasing the patients’ compliance and therapeutic efficacy. As a unique nano-carrier, supermolecular aggregation nanovehicle has attracted increasing interests due to the following advantages: announcing drug loading efficacy, pronouncing in vivo performance and simplified production process. Methods In this study, the supermolecular aggregation nanovehicle of bortezomib (BTZ) was prepared to treat breast cancer. Results Although many supermolecular nanovehicles are inclined to disintegrate due to the weak intermolecular interactions among the components, the BTZ supermolecules are satisfying stable. To shed light on the reasons behind this, the forces driving the formation of the nanovehicles were detailed investigated. In other words, the interactions among BTZ and other two components were studied to characterize the nanovehicles and ensure its stability. Conclusions Due to the promising tumor targeting ability of the BTZ nanovehicles, the supermolecule displayed promising tumor curing effects and negligible systemic toxicity.http://link.springer.com/article/10.1186/s12951-020-00612-7Supermolecular nanovehiclesBortezomib (BTZ)Intermolecular interactions |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming-yue Chen Ze-kuan Xiao Xue-ping Lei Jie-xia Li Xi-yong Yu Jian-ye Zhang Guo-dong Ye Yu-juan Guo Guangquan Mo Chu-wen Li Yu Zhang Ling-min Zhang Zhi-qiang Lin Ji-jun Fu |
spellingShingle |
Ming-yue Chen Ze-kuan Xiao Xue-ping Lei Jie-xia Li Xi-yong Yu Jian-ye Zhang Guo-dong Ye Yu-juan Guo Guangquan Mo Chu-wen Li Yu Zhang Ling-min Zhang Zhi-qiang Lin Ji-jun Fu Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles Journal of Nanobiotechnology Supermolecular nanovehicles Bortezomib (BTZ) Intermolecular interactions |
author_facet |
Ming-yue Chen Ze-kuan Xiao Xue-ping Lei Jie-xia Li Xi-yong Yu Jian-ye Zhang Guo-dong Ye Yu-juan Guo Guangquan Mo Chu-wen Li Yu Zhang Ling-min Zhang Zhi-qiang Lin Ji-jun Fu |
author_sort |
Ming-yue Chen |
title |
Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles |
title_short |
Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles |
title_full |
Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles |
title_fullStr |
Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles |
title_full_unstemmed |
Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles |
title_sort |
preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles |
publisher |
BMC |
series |
Journal of Nanobiotechnology |
issn |
1477-3155 |
publishDate |
2020-04-01 |
description |
Abstract Backgrounds Intolerable toxicity and unsatisfactory therapeutic effects are still big problems retarding the use of chemotherapy against cancer. Nano-drug delivery system promised a lot in increasing the patients’ compliance and therapeutic efficacy. As a unique nano-carrier, supermolecular aggregation nanovehicle has attracted increasing interests due to the following advantages: announcing drug loading efficacy, pronouncing in vivo performance and simplified production process. Methods In this study, the supermolecular aggregation nanovehicle of bortezomib (BTZ) was prepared to treat breast cancer. Results Although many supermolecular nanovehicles are inclined to disintegrate due to the weak intermolecular interactions among the components, the BTZ supermolecules are satisfying stable. To shed light on the reasons behind this, the forces driving the formation of the nanovehicles were detailed investigated. In other words, the interactions among BTZ and other two components were studied to characterize the nanovehicles and ensure its stability. Conclusions Due to the promising tumor targeting ability of the BTZ nanovehicles, the supermolecule displayed promising tumor curing effects and negligible systemic toxicity. |
topic |
Supermolecular nanovehicles Bortezomib (BTZ) Intermolecular interactions |
url |
http://link.springer.com/article/10.1186/s12951-020-00612-7 |
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