Association Study between Functional Polymorphisms of MMP9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population

• Main Authors: Sima SABBAGH, Zakiye NADEALI, Leila DEHGHANI, Vahid SHAYGANNEJAD, Majid REZVANI, Masih SABOORI, Hamid GANJI, Soheil TAHANI, Farzaneh DEHGHANI, Saman HOSSEINZADEH, Elnaz MARZBANI, Peiman SHAFIEI
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2019-09-01
• Series: Iranian Journal of Public Health
• Subjects: Multiple sclerosis; MMP-9 gene; Polymorphism; Association study
• Online Access: https://ijph.tums.ac.ir/index.php/ijph/article/view/18257
• ISSN: 2251-6085; 2251-6093

Background: Matrix metalloproteinase-9 (MMP-9) polymorphisms, C−1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of MMP-9 polymorphisms in Iranian MS patients is studied. Methods: Association of MMP-9 mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017.  Results: -1562 T allele of MMP-9 was associated with increased MS risk. However, we found no overall significant effect of −90 (CA)n repeat on MS susceptibility. Conclusion: For as much as MMP-9 molecule is a potential target for MS therapy, to determine whether any of MMP-9 polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA repeats, further research is needed before proposing any definite conclusion.