How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence
Abstract Introduction Understanding the emotional responsivity style and neurocognitive profiles of depression‐related processes in at‐risk youth may be helpful in revealing those most likely to develop affective disorders. However, the multiplicity of biopsychosocial risk factors makes it difficult...
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doaj-59f73d1e382842e38d38e76baa9c776c2021-05-14T04:41:30ZengWileyBrain and Behavior2162-32792021-05-01115n/an/a10.1002/brb3.2005How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescenceJason Stretton0Nicholas D Walsh1Dean Mobbs2Susanne Schweizer3Anne‐Laura vanHarmelen4Michael Lombardo5Ian Goodyer6Tim Dalgleish7Medical Research Council Cognition and Brain Sciences Unit University of Cambridge Cambridge UKSchool of Psychology Faculty of Social Sciences University of East Anglia Norwich UKDivision of Humanities and Social Sciences California Institute of Technology Pasadena CA USADivision of Psychology and Language Sciences University College London London UKDevelopmental Psychiatry Section Department of Psychiatry University of Cambridge Cambridge UKDepartment of Psychology and Center for Applied Neuroscience University of Cyprus Nicosia CyprusDevelopmental Psychiatry Section Department of Psychiatry University of Cambridge Cambridge UKMedical Research Council Cognition and Brain Sciences Unit University of Cambridge Cambridge UKAbstract Introduction Understanding the emotional responsivity style and neurocognitive profiles of depression‐related processes in at‐risk youth may be helpful in revealing those most likely to develop affective disorders. However, the multiplicity of biopsychosocial risk factors makes it difficult to disentangle unique and combined effects at a neurobiological level. Methods In a population‐derived sample of 56 older adolescents (aged 17–20), we adopted partial least squares regression and correlation models to explore the relationships between multivariate biopsychosocial risks for later depression, emotional response style, and fMRI activity, to rejecting and inclusive social feedback. Results Behaviorally, higher depressive risk was associated with both reduced negative affect following negative social feedback and reduced positive affect following positive social feedback. In response to both cues of rejection and inclusion, we observed a general neural pattern of increased cingulate, temporal, and striatal activity in the brain. Secondly, in response to rejection only, we observed a pattern of activity in ostensibly executive control‐ and emotion regulation‐related brain regions encompassing fronto‐parietal brain networks including the angular gyrus. Conclusion The results suggest that risk for depression is associated with a pervasive emotional insensitivity in the face of positive and negative social feedback.https://doi.org/10.1002/brb3.2005adolescencebiopsychosocialdepressive riskemotion context insensitivitypartial least squares |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jason Stretton Nicholas D Walsh Dean Mobbs Susanne Schweizer Anne‐Laura vanHarmelen Michael Lombardo Ian Goodyer Tim Dalgleish |
spellingShingle |
Jason Stretton Nicholas D Walsh Dean Mobbs Susanne Schweizer Anne‐Laura vanHarmelen Michael Lombardo Ian Goodyer Tim Dalgleish How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence Brain and Behavior adolescence biopsychosocial depressive risk emotion context insensitivity partial least squares |
author_facet |
Jason Stretton Nicholas D Walsh Dean Mobbs Susanne Schweizer Anne‐Laura vanHarmelen Michael Lombardo Ian Goodyer Tim Dalgleish |
author_sort |
Jason Stretton |
title |
How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence |
title_short |
How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence |
title_full |
How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence |
title_fullStr |
How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence |
title_full_unstemmed |
How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence |
title_sort |
how biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence |
publisher |
Wiley |
series |
Brain and Behavior |
issn |
2162-3279 |
publishDate |
2021-05-01 |
description |
Abstract Introduction Understanding the emotional responsivity style and neurocognitive profiles of depression‐related processes in at‐risk youth may be helpful in revealing those most likely to develop affective disorders. However, the multiplicity of biopsychosocial risk factors makes it difficult to disentangle unique and combined effects at a neurobiological level. Methods In a population‐derived sample of 56 older adolescents (aged 17–20), we adopted partial least squares regression and correlation models to explore the relationships between multivariate biopsychosocial risks for later depression, emotional response style, and fMRI activity, to rejecting and inclusive social feedback. Results Behaviorally, higher depressive risk was associated with both reduced negative affect following negative social feedback and reduced positive affect following positive social feedback. In response to both cues of rejection and inclusion, we observed a general neural pattern of increased cingulate, temporal, and striatal activity in the brain. Secondly, in response to rejection only, we observed a pattern of activity in ostensibly executive control‐ and emotion regulation‐related brain regions encompassing fronto‐parietal brain networks including the angular gyrus. Conclusion The results suggest that risk for depression is associated with a pervasive emotional insensitivity in the face of positive and negative social feedback. |
topic |
adolescence biopsychosocial depressive risk emotion context insensitivity partial least squares |
url |
https://doi.org/10.1002/brb3.2005 |
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