Molecular Genetics in Epstein–Barr Virus-Associated Malignancies
Global genomic studies have detected the role of genomic alterations in the pathogenesis of Epstein–Barr virus (EBV)-associated tumors. EBV oncoproteins cause a vital shift of EBV from an infectious virus to an oncogenic form during the latent and lytic phase within the lymphoid B cells and epitheli...
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doaj-5a0e288e30724dbfab7cafebd45868ca2021-07-23T13:50:20ZengMDPI AGLife2075-17292021-06-011159359310.3390/life11070593Molecular Genetics in Epstein–Barr Virus-Associated MalignanciesSrikanth Umakanthan0Maryann M Bukelo1Pathology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, Mount Hope, Trinidad and TobagoLaboratory Services, Department of Anatomical Pathology, Eric Williams Medical Sciences Complex, North Central Regional Health Authority, Champs Fleurs, Trinidad and TobagoGlobal genomic studies have detected the role of genomic alterations in the pathogenesis of Epstein–Barr virus (EBV)-associated tumors. EBV oncoproteins cause a vital shift of EBV from an infectious virus to an oncogenic form during the latent and lytic phase within the lymphoid B cells and epithelial cells. This epigenetic alteration modulates the virus and host genomes and inactivates and disrupts numerous tumor suppressors and signaling pathways. Genomic profiling has played the main role in identifying EBV cancer pathogenesis and its related targeted therapies. This article reviews the role of genetic changes in EBV-associated lymphomas and carcinomas. This includes the prolific molecular genesis, key diagnostic tools, and target-specific drugs that have been in recent clinical use.https://www.mdpi.com/2075-1729/11/7/593Epstein–Barr virusgenomepathogenesislymphomascarcinomas |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Srikanth Umakanthan Maryann M Bukelo |
spellingShingle |
Srikanth Umakanthan Maryann M Bukelo Molecular Genetics in Epstein–Barr Virus-Associated Malignancies Life Epstein–Barr virus genome pathogenesis lymphomas carcinomas |
author_facet |
Srikanth Umakanthan Maryann M Bukelo |
author_sort |
Srikanth Umakanthan |
title |
Molecular Genetics in Epstein–Barr Virus-Associated Malignancies |
title_short |
Molecular Genetics in Epstein–Barr Virus-Associated Malignancies |
title_full |
Molecular Genetics in Epstein–Barr Virus-Associated Malignancies |
title_fullStr |
Molecular Genetics in Epstein–Barr Virus-Associated Malignancies |
title_full_unstemmed |
Molecular Genetics in Epstein–Barr Virus-Associated Malignancies |
title_sort |
molecular genetics in epstein–barr virus-associated malignancies |
publisher |
MDPI AG |
series |
Life |
issn |
2075-1729 |
publishDate |
2021-06-01 |
description |
Global genomic studies have detected the role of genomic alterations in the pathogenesis of Epstein–Barr virus (EBV)-associated tumors. EBV oncoproteins cause a vital shift of EBV from an infectious virus to an oncogenic form during the latent and lytic phase within the lymphoid B cells and epithelial cells. This epigenetic alteration modulates the virus and host genomes and inactivates and disrupts numerous tumor suppressors and signaling pathways. Genomic profiling has played the main role in identifying EBV cancer pathogenesis and its related targeted therapies. This article reviews the role of genetic changes in EBV-associated lymphomas and carcinomas. This includes the prolific molecular genesis, key diagnostic tools, and target-specific drugs that have been in recent clinical use. |
topic |
Epstein–Barr virus genome pathogenesis lymphomas carcinomas |
url |
https://www.mdpi.com/2075-1729/11/7/593 |
work_keys_str_mv |
AT srikanthumakanthan moleculargeneticsinepsteinbarrvirusassociatedmalignancies AT maryannmbukelo moleculargeneticsinepsteinbarrvirusassociatedmalignancies |
_version_ |
1721287453050929152 |