Molecular Genetics in Epstein–Barr Virus-Associated Malignancies

Global genomic studies have detected the role of genomic alterations in the pathogenesis of Epstein–Barr virus (EBV)-associated tumors. EBV oncoproteins cause a vital shift of EBV from an infectious virus to an oncogenic form during the latent and lytic phase within the lymphoid B cells and epitheli...

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Main Authors:	Srikanth Umakanthan, Maryann M Bukelo
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	Life
Subjects:	Epstein–Barr virus genome pathogenesis lymphomas carcinomas
Online Access:	https://www.mdpi.com/2075-1729/11/7/593

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spelling	doaj-5a0e288e30724dbfab7cafebd45868ca2021-07-23T13:50:20ZengMDPI AGLife2075-17292021-06-011159359310.3390/life11070593Molecular Genetics in Epstein–Barr Virus-Associated MalignanciesSrikanth Umakanthan0Maryann M Bukelo1Pathology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, Mount Hope, Trinidad and TobagoLaboratory Services, Department of Anatomical Pathology, Eric Williams Medical Sciences Complex, North Central Regional Health Authority, Champs Fleurs, Trinidad and TobagoGlobal genomic studies have detected the role of genomic alterations in the pathogenesis of Epstein–Barr virus (EBV)-associated tumors. EBV oncoproteins cause a vital shift of EBV from an infectious virus to an oncogenic form during the latent and lytic phase within the lymphoid B cells and epithelial cells. This epigenetic alteration modulates the virus and host genomes and inactivates and disrupts numerous tumor suppressors and signaling pathways. Genomic profiling has played the main role in identifying EBV cancer pathogenesis and its related targeted therapies. This article reviews the role of genetic changes in EBV-associated lymphomas and carcinomas. This includes the prolific molecular genesis, key diagnostic tools, and target-specific drugs that have been in recent clinical use.https://www.mdpi.com/2075-1729/11/7/593Epstein–Barr virusgenomepathogenesislymphomascarcinomas
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Srikanth Umakanthan Maryann M Bukelo
spellingShingle	Srikanth Umakanthan Maryann M Bukelo Molecular Genetics in Epstein–Barr Virus-Associated Malignancies Life Epstein–Barr virus genome pathogenesis lymphomas carcinomas
author_facet	Srikanth Umakanthan Maryann M Bukelo
author_sort	Srikanth Umakanthan
title	Molecular Genetics in Epstein–Barr Virus-Associated Malignancies
title_short	Molecular Genetics in Epstein–Barr Virus-Associated Malignancies
title_full	Molecular Genetics in Epstein–Barr Virus-Associated Malignancies
title_fullStr	Molecular Genetics in Epstein–Barr Virus-Associated Malignancies
title_full_unstemmed	Molecular Genetics in Epstein–Barr Virus-Associated Malignancies
title_sort	molecular genetics in epstein–barr virus-associated malignancies
publisher	MDPI AG
series	Life
issn	2075-1729
publishDate	2021-06-01
description	Global genomic studies have detected the role of genomic alterations in the pathogenesis of Epstein–Barr virus (EBV)-associated tumors. EBV oncoproteins cause a vital shift of EBV from an infectious virus to an oncogenic form during the latent and lytic phase within the lymphoid B cells and epithelial cells. This epigenetic alteration modulates the virus and host genomes and inactivates and disrupts numerous tumor suppressors and signaling pathways. Genomic profiling has played the main role in identifying EBV cancer pathogenesis and its related targeted therapies. This article reviews the role of genetic changes in EBV-associated lymphomas and carcinomas. This includes the prolific molecular genesis, key diagnostic tools, and target-specific drugs that have been in recent clinical use.
topic	Epstein–Barr virus genome pathogenesis lymphomas carcinomas
url	https://www.mdpi.com/2075-1729/11/7/593
work_keys_str_mv	AT srikanthumakanthan moleculargeneticsinepsteinbarrvirusassociatedmalignancies AT maryannmbukelo moleculargeneticsinepsteinbarrvirusassociatedmalignancies
_version_	1721287453050929152

Molecular Genetics in Epstein–Barr Virus-Associated Malignancies

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