IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity

Abstract Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many patients with OA are obese and increased adiposity is associated with chronic inflammation, we investigated whether obese patients with hip...

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Bibliographic Details
Main Authors: Mark J. Pearson, Dietmar Herndler-Brandstetter, Mohammad A. Tariq, Thomas A. Nicholson, Ashleigh M. Philp, Hannah L. Smith, Edward T. Davis, Simon W. Jones, Janet M. Lord
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03759-w