Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence
Somatostatin (SOM) and somatostatin receptors (SSTR1–4) are present in all olfactory structures, including the olfactory bulb (OB), where SOM modulates physiological gamma rhythms and olfactory discrimination responses. In this work, histological, viral tracing and transgenic approaches were used to...
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doaj-5a2a2fa3dbbe4006a40324964254555f2020-11-25T00:39:16ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-04-011310.3389/fnbeh.2019.00061428833Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral EvidenceSonia Nocera0Sonia Nocera1Axelle Simon2Axelle Simon3Oriane Fiquet4Oriane Fiquet5Ying Chen6Ying Chen7Jean Gascuel8Frédérique Datiche9Nanette Schneider10Jacques Epelbaum11Jacques Epelbaum12Cécile Viollet13Cécile Viollet14INSERM, UMR 894-Center for Psychiatry and Neuroscience (CPN), Paris, FranceUniversité Paris Descartes-Sorbonne Paris Cité, Paris, FranceINSERM, UMR 894-Center for Psychiatry and Neuroscience (CPN), Paris, FranceUniversité Paris Descartes-Sorbonne Paris Cité, Paris, FranceINSERM, UMR 894-Center for Psychiatry and Neuroscience (CPN), Paris, FranceUniversité Paris Descartes-Sorbonne Paris Cité, Paris, FranceINSERM, UMR 894-Center for Psychiatry and Neuroscience (CPN), Paris, FranceUniversité Paris Descartes-Sorbonne Paris Cité, Paris, FranceCNRS UMR 6265—Centre des Sciences du Goût et de l’Alimentation (CSGA), Dijon, FranceCNRS UMR 6265—Centre des Sciences du Goût et de l’Alimentation (CSGA), Dijon, FranceCNRS UMR 6265—Centre des Sciences du Goût et de l’Alimentation (CSGA), Dijon, FranceINSERM, UMR 894-Center for Psychiatry and Neuroscience (CPN), Paris, FranceUniversité Paris Descartes-Sorbonne Paris Cité, Paris, FranceINSERM, UMR 894-Center for Psychiatry and Neuroscience (CPN), Paris, FranceUniversité Paris Descartes-Sorbonne Paris Cité, Paris, FranceSomatostatin (SOM) and somatostatin receptors (SSTR1–4) are present in all olfactory structures, including the olfactory bulb (OB), where SOM modulates physiological gamma rhythms and olfactory discrimination responses. In this work, histological, viral tracing and transgenic approaches were used to characterize SOM cellular targets in the murine OB. We demonstrate that SOM targets all levels of mitral dendritic processes in the OB with somatostatin receptor 2 (SSTR2) detected in the dendrites of previously uncharacterized mitral-like cells. We show that inhibitory interneurons of the glomerular layer (GL) express SSTR4 while SSTR3 is confined to the granule cell layer (GCL). Furthermore, SOM cells in the OB receive synaptic inputs from olfactory cortical afferents. Behavioral studies demonstrate that genetic deletion of SSTR4, SSTR2 or SOM differentially affects olfactory performance. SOM or SSTR4 deletion have no major effect on olfactory behavioral performances while SSTR2 deletion impacts olfactory detection and discrimination behaviors. Altogether, these results describe novel anatomical and behavioral contributions of SOM, SSTR2 and SSTR4 receptors in olfactory processing.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00061/fullsomatostatin receptormitral cellsinterneuronsolfactionSSTR3SSTR2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sonia Nocera Sonia Nocera Axelle Simon Axelle Simon Oriane Fiquet Oriane Fiquet Ying Chen Ying Chen Jean Gascuel Frédérique Datiche Nanette Schneider Jacques Epelbaum Jacques Epelbaum Cécile Viollet Cécile Viollet |
spellingShingle |
Sonia Nocera Sonia Nocera Axelle Simon Axelle Simon Oriane Fiquet Oriane Fiquet Ying Chen Ying Chen Jean Gascuel Frédérique Datiche Nanette Schneider Jacques Epelbaum Jacques Epelbaum Cécile Viollet Cécile Viollet Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence Frontiers in Behavioral Neuroscience somatostatin receptor mitral cells interneurons olfaction SSTR3 SSTR2 |
author_facet |
Sonia Nocera Sonia Nocera Axelle Simon Axelle Simon Oriane Fiquet Oriane Fiquet Ying Chen Ying Chen Jean Gascuel Frédérique Datiche Nanette Schneider Jacques Epelbaum Jacques Epelbaum Cécile Viollet Cécile Viollet |
author_sort |
Sonia Nocera |
title |
Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence |
title_short |
Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence |
title_full |
Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence |
title_fullStr |
Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence |
title_full_unstemmed |
Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence |
title_sort |
somatostatin serves a modulatory role in the mouse olfactory bulb: neuroanatomical and behavioral evidence |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2019-04-01 |
description |
Somatostatin (SOM) and somatostatin receptors (SSTR1–4) are present in all olfactory structures, including the olfactory bulb (OB), where SOM modulates physiological gamma rhythms and olfactory discrimination responses. In this work, histological, viral tracing and transgenic approaches were used to characterize SOM cellular targets in the murine OB. We demonstrate that SOM targets all levels of mitral dendritic processes in the OB with somatostatin receptor 2 (SSTR2) detected in the dendrites of previously uncharacterized mitral-like cells. We show that inhibitory interneurons of the glomerular layer (GL) express SSTR4 while SSTR3 is confined to the granule cell layer (GCL). Furthermore, SOM cells in the OB receive synaptic inputs from olfactory cortical afferents. Behavioral studies demonstrate that genetic deletion of SSTR4, SSTR2 or SOM differentially affects olfactory performance. SOM or SSTR4 deletion have no major effect on olfactory behavioral performances while SSTR2 deletion impacts olfactory detection and discrimination behaviors. Altogether, these results describe novel anatomical and behavioral contributions of SOM, SSTR2 and SSTR4 receptors in olfactory processing. |
topic |
somatostatin receptor mitral cells interneurons olfaction SSTR3 SSTR2 |
url |
https://www.frontiersin.org/article/10.3389/fnbeh.2019.00061/full |
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