A brief discussion on pathogenesis of primary biliary cirrhosis
The pathogenesis of primary biliary cirrhosis (PBC) is unknown. Researchers have found that monozygotic twins have a higher concordance rate for PBC than dizygotic twins, and the phenomenon of familial aggregation and the results of genome-wide association studies also demonstrate the importance of...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Hepatology
2013-11-01
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| Series: | Linchuang Gandanbing Zazhi |
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| Online Access: | http://www.lcgdbzz.org/qk_content.asp?id=5533&ClassID=101494815 |
| Summary: | The pathogenesis of primary biliary cirrhosis (PBC) is unknown. Researchers have found that monozygotic twins have a higher concordance rate for PBC than dizygotic twins, and the phenomenon of familial aggregation and the results of genome-wide association studies also demonstrate the importance of genetic factors in the pathogenesis of PBC. The epidemiological investigations and animal model experiments show that xenobiotics and infectious molecules may play a role in the pathogenesis of PBC by molecular mimicry. The appearance of highly specific serum antimitochondrial antibodies and autoreactive T cells suggests a possible autoimmune pathogenesis of PBC. The histopathological features of PBC are inflammation in the portal area and immune-mediated intrahepatic bile duct destruction. The pathogenesis of PBC is summarized from the aspects of genetic factors, environmental exposure, autoimmune response, and liver pathology, and the importance of immune imbalance is emphasized. |
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| ISSN: | 1001-5256 1001-5256 |