EXPERIENCE OF APPLICATION AND SAFETY ASSESSMENT OF THE 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE IN UNDER-5 CHILDREN
Compulsory use of the 7-valent pneumococcal conjugate vaccine in the framework of national pediatric immunization schedules of the developed countries resulted in significant decrease in the prevalence of the pneumococcal infections induced by the vaccinal serotypes. However, a growth in prevalence...
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doaj-5a35145f8c1c4b64a74ef574e952692e2021-07-28T16:32:27ZengPaediatrician Publishers, LLCPediatričeskaâ Farmakologiâ1727-57762500-30892014-09-01115596410.15690/pf.v11i5.116653EXPERIENCE OF APPLICATION AND SAFETY ASSESSMENT OF THE 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE IN UNDER-5 CHILDRENM. V. Fedoseenko0D. A. Novikova1N. E. Tkachenko2M. I. Broeva3T. A. Grechukha4A. G. Gaivoronskaya5V. V. Chernikov6Scientific Center of Children’s Health, Moscow, Russian Federation Sechenov First Moscow State Medical University, Moscow, Russian FederationScientific Center of Children’s Health, Moscow, Russian FederationScientific Center of Children’s Health, Moscow, Russian FederationScientific Center of Children’s Health, Moscow, Russian Federation Sechenov First Moscow State Medical University, Moscow, Russian FederationScientific Center of Children’s Health, Moscow, Russian FederationScientific Center of Children’s Health, Moscow, Russian FederationScientific Center of Children’s Health, Moscow, Russian FederationCompulsory use of the 7-valent pneumococcal conjugate vaccine in the framework of national pediatric immunization schedules of the developed countries resulted in significant decrease in the prevalence of the pneumococcal infections induced by the vaccinal serotypes. However, a growth in prevalence of the pneumonia and acute otitis media caused by non-vaccinal strains has also been observed. This required introduction of a new 13-valent pneumococcal conjugate vaccine with a wider range of pneumococcal population coverage. The experience of application accumulated in various countries (2010 onwards) and results of the authors’ observations indicate high safety of the 13-valent pneumococcal conjugate vaccine for both healthy under-5 children and patients with various medical issues. The article presents results of the 13-valent pneumococcal conjugate vaccination tolerance assessment. The study involved 110 children from 2 months to 5 years of age. In most cases immunization concurred with other pediatric vaccines. The incidence of local reactions in vaccinated children did not exceed 33%, of generalized reactions – 11%. The authors observed a comparable incidence of side reactions in both virtually healthy children and children with various medical issues.https://www.pedpharma.ru/jour/article/view/53pneumococcal infectionvaccination13-valent pneumococcal conjugate vaccine (pcv13)vaccination safetychildren |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. V. Fedoseenko D. A. Novikova N. E. Tkachenko M. I. Broeva T. A. Grechukha A. G. Gaivoronskaya V. V. Chernikov |
spellingShingle |
M. V. Fedoseenko D. A. Novikova N. E. Tkachenko M. I. Broeva T. A. Grechukha A. G. Gaivoronskaya V. V. Chernikov EXPERIENCE OF APPLICATION AND SAFETY ASSESSMENT OF THE 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE IN UNDER-5 CHILDREN Pediatričeskaâ Farmakologiâ pneumococcal infection vaccination 13-valent pneumococcal conjugate vaccine (pcv13) vaccination safety children |
author_facet |
M. V. Fedoseenko D. A. Novikova N. E. Tkachenko M. I. Broeva T. A. Grechukha A. G. Gaivoronskaya V. V. Chernikov |
author_sort |
M. V. Fedoseenko |
title |
EXPERIENCE OF APPLICATION AND SAFETY ASSESSMENT OF THE 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE IN UNDER-5 CHILDREN |
title_short |
EXPERIENCE OF APPLICATION AND SAFETY ASSESSMENT OF THE 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE IN UNDER-5 CHILDREN |
title_full |
EXPERIENCE OF APPLICATION AND SAFETY ASSESSMENT OF THE 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE IN UNDER-5 CHILDREN |
title_fullStr |
EXPERIENCE OF APPLICATION AND SAFETY ASSESSMENT OF THE 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE IN UNDER-5 CHILDREN |
title_full_unstemmed |
EXPERIENCE OF APPLICATION AND SAFETY ASSESSMENT OF THE 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE IN UNDER-5 CHILDREN |
title_sort |
experience of application and safety assessment of the 13-valent pneumococcal conjugate vaccine in under-5 children |
publisher |
Paediatrician Publishers, LLC |
series |
Pediatričeskaâ Farmakologiâ |
issn |
1727-5776 2500-3089 |
publishDate |
2014-09-01 |
description |
Compulsory use of the 7-valent pneumococcal conjugate vaccine in the framework of national pediatric immunization schedules of the developed countries resulted in significant decrease in the prevalence of the pneumococcal infections induced by the vaccinal serotypes. However, a growth in prevalence of the pneumonia and acute otitis media caused by non-vaccinal strains has also been observed. This required introduction of a new 13-valent pneumococcal conjugate vaccine with a wider range of pneumococcal population coverage. The experience of application accumulated in various countries (2010 onwards) and results of the authors’ observations indicate high safety of the 13-valent pneumococcal conjugate vaccine for both healthy under-5 children and patients with various medical issues. The article presents results of the 13-valent pneumococcal conjugate vaccination tolerance assessment. The study involved 110 children from 2 months to 5 years of age. In most cases immunization concurred with other pediatric vaccines. The incidence of local reactions in vaccinated children did not exceed 33%, of generalized reactions – 11%. The authors observed a comparable incidence of side reactions in both virtually healthy children and children with various medical issues. |
topic |
pneumococcal infection vaccination 13-valent pneumococcal conjugate vaccine (pcv13) vaccination safety children |
url |
https://www.pedpharma.ru/jour/article/view/53 |
work_keys_str_mv |
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