Chronic Supplementation with a Mix of <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i> Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice
<strong>Background</strong>: Two different species of sage, <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i>, have demonstrated activities in cognitive function during preclinical and clinical studies related to impaired health situations or single admi...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/12/6/1777 |
id |
doaj-5a3933190bc2401eb9d491c36dcf39ef |
---|---|
record_format |
Article |
spelling |
doaj-5a3933190bc2401eb9d491c36dcf39ef2020-11-25T03:20:36ZengMDPI AGNutrients2072-66432020-06-01121777177710.3390/nu12061777Chronic Supplementation with a Mix of <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i> Improves Morris Water Maze Learning in Normal Adult C57Bl/6J MiceAnne-Laure Dinel0Céline Lucas1Damien Guillemet2Sophie Layé3Véronique Pallet4Corinne Joffre5Université de Bordeaux, INRAE, Bordeaux INP, NutriNeuro Laboratory, 146 rue Léo Saignat, 33076 Bordeaux, FranceNutriBrain Research and Technology Transfer, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, FranceNexira, 129 Chemin de Croisset, 76000 Rouen, FranceUniversité de Bordeaux, INRAE, Bordeaux INP, NutriNeuro Laboratory, 146 rue Léo Saignat, 33076 Bordeaux, FranceUniversité de Bordeaux, INRAE, Bordeaux INP, NutriNeuro Laboratory, 146 rue Léo Saignat, 33076 Bordeaux, FranceUniversité de Bordeaux, INRAE, Bordeaux INP, NutriNeuro Laboratory, 146 rue Léo Saignat, 33076 Bordeaux, France<strong>Background</strong>: Two different species of sage, <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i>, have demonstrated activities in cognitive function during preclinical and clinical studies related to impaired health situations or single administration. Different memory processes have been described to be significantly and positively impacted. <b>Objective: </b>Our objective is to explore the potential of these <i>Salvia,</i> and their additional activities, in healthy situations, and during prolonged administration, on memory and subsequent mechanisms of action related to putative effects. <b>Design: </b>This mouse study has implicated four investigational arms dedicated to control, <i>Salvia officinalis</i> aqueous extract, <i>Salvia lavandulaefoli</i><i>a</i>-encapsulated essential oil and a mix thereof (Cognivia™) for 2 weeks of administration. Cognitive functions have been assessed throughout Y-maze and Morris water maze models. The impact of supplementation on lipid peroxidation, oxidative stress, neurogenesis, neuronal activity, neurotrophins, neurotrophin receptors, CaM kinase II and glucocorticoid receptors has been assessed via post-interventional tissue collection. <b>Results: </b>All <i>Salvia</i> groups had a significant effect on Y-maze markers on day 1 of administration. Only the mix of two <i>Salvia</i> species demonstrated significant improvements in Morris water maze markers at the end of administration. Considering all biological and histological markers, we did not observe any significant effect of S. <i>officinalis</i>, S. <i>lavandulaefoli</i><i>a</i> and a mix of Salvia supplementation on lipid peroxidation, oxidative stress and neuronal plasticity (neurogenesis, neuronal activity, neurotrophins). Interestingly, CaM kinase II protein expression is significantly increased in animals supplemented with Salvia. <b>Conclusion: </b>The activities of <i>Salvia</i> alone after one intake have been confirmed; however, a particular combination of different types of Salvia have been shown to improve memory and present specific synergistic effects after chronic administration in healthy mice.https://www.mdpi.com/2072-6643/12/6/1777<i>Salvia officinalis</i><i>Salvia lavandulaefolia</i>cognitionshort-term memoryCaMKIIspatial memory |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anne-Laure Dinel Céline Lucas Damien Guillemet Sophie Layé Véronique Pallet Corinne Joffre |
spellingShingle |
Anne-Laure Dinel Céline Lucas Damien Guillemet Sophie Layé Véronique Pallet Corinne Joffre Chronic Supplementation with a Mix of <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i> Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice Nutrients <i>Salvia officinalis</i> <i>Salvia lavandulaefolia</i> cognition short-term memory CaMKII spatial memory |
author_facet |
Anne-Laure Dinel Céline Lucas Damien Guillemet Sophie Layé Véronique Pallet Corinne Joffre |
author_sort |
Anne-Laure Dinel |
title |
Chronic Supplementation with a Mix of <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i> Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice |
title_short |
Chronic Supplementation with a Mix of <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i> Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice |
title_full |
Chronic Supplementation with a Mix of <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i> Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice |
title_fullStr |
Chronic Supplementation with a Mix of <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i> Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice |
title_full_unstemmed |
Chronic Supplementation with a Mix of <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i> Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice |
title_sort |
chronic supplementation with a mix of <i>salvia officinalis</i> and <i>salvia lavandulaefolia</i> improves morris water maze learning in normal adult c57bl/6j mice |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-06-01 |
description |
<strong>Background</strong>: Two different species of sage, <i>Salvia officinalis</i> and <i>Salvia lavandulaefolia</i>, have demonstrated activities in cognitive function during preclinical and clinical studies related to impaired health situations or single administration. Different memory processes have been described to be significantly and positively impacted. <b>Objective: </b>Our objective is to explore the potential of these <i>Salvia,</i> and their additional activities, in healthy situations, and during prolonged administration, on memory and subsequent mechanisms of action related to putative effects. <b>Design: </b>This mouse study has implicated four investigational arms dedicated to control, <i>Salvia officinalis</i> aqueous extract, <i>Salvia lavandulaefoli</i><i>a</i>-encapsulated essential oil and a mix thereof (Cognivia™) for 2 weeks of administration. Cognitive functions have been assessed throughout Y-maze and Morris water maze models. The impact of supplementation on lipid peroxidation, oxidative stress, neurogenesis, neuronal activity, neurotrophins, neurotrophin receptors, CaM kinase II and glucocorticoid receptors has been assessed via post-interventional tissue collection. <b>Results: </b>All <i>Salvia</i> groups had a significant effect on Y-maze markers on day 1 of administration. Only the mix of two <i>Salvia</i> species demonstrated significant improvements in Morris water maze markers at the end of administration. Considering all biological and histological markers, we did not observe any significant effect of S. <i>officinalis</i>, S. <i>lavandulaefoli</i><i>a</i> and a mix of Salvia supplementation on lipid peroxidation, oxidative stress and neuronal plasticity (neurogenesis, neuronal activity, neurotrophins). Interestingly, CaM kinase II protein expression is significantly increased in animals supplemented with Salvia. <b>Conclusion: </b>The activities of <i>Salvia</i> alone after one intake have been confirmed; however, a particular combination of different types of Salvia have been shown to improve memory and present specific synergistic effects after chronic administration in healthy mice. |
topic |
<i>Salvia officinalis</i> <i>Salvia lavandulaefolia</i> cognition short-term memory CaMKII spatial memory |
url |
https://www.mdpi.com/2072-6643/12/6/1777 |
work_keys_str_mv |
AT annelauredinel chronicsupplementationwithamixofisalviaofficinalisiandisalvialavandulaefoliaiimprovesmorriswatermazelearninginnormaladultc57bl6jmice AT celinelucas chronicsupplementationwithamixofisalviaofficinalisiandisalvialavandulaefoliaiimprovesmorriswatermazelearninginnormaladultc57bl6jmice AT damienguillemet chronicsupplementationwithamixofisalviaofficinalisiandisalvialavandulaefoliaiimprovesmorriswatermazelearninginnormaladultc57bl6jmice AT sophielaye chronicsupplementationwithamixofisalviaofficinalisiandisalvialavandulaefoliaiimprovesmorriswatermazelearninginnormaladultc57bl6jmice AT veroniquepallet chronicsupplementationwithamixofisalviaofficinalisiandisalvialavandulaefoliaiimprovesmorriswatermazelearninginnormaladultc57bl6jmice AT corinnejoffre chronicsupplementationwithamixofisalviaofficinalisiandisalvialavandulaefoliaiimprovesmorriswatermazelearninginnormaladultc57bl6jmice |
_version_ |
1724617787097219072 |