Changes in malaria patterns in Brazil over 28 years (1990–2017): results from the Global Burden of Disease Study 2017
Abstract Background This study presents the malaria burden in Brazil from 1990 to 2017 using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), by analyzing disease burden indicators in federated units of the Legal Amazon and Extra-Amazon regions, as well as d...
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doaj-5a5181fe508b422c8244132cf9bb4b352020-11-25T02:06:07ZengBMCPopulation Health Metrics1478-79542020-09-0118S111510.1186/s12963-020-00211-6Changes in malaria patterns in Brazil over 28 years (1990–2017): results from the Global Burden of Disease Study 2017Juliana Maria Trindade Bezerra0David Soeiro Barbosa1Francisco Rogerlândio Martins-Melo2Guilherme Loureiro Werneck3Érika Martins Braga4Pedro Luiz Tauil5Mariângela Carneiro6Laboratory of Epidemiology of Infectious and Parasitic Diseases, Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas GeraisLaboratory of Epidemiology of Infectious and Parasitic Diseases, Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas GeraisFederal Institute of Education, Science, and Technology of CearáInstitute for Public Health Studies, Universidade Federal do Rio de JaneiroLaboratory of Malaria, Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas GeraisSchool of Medicine, Postgraduate Program in Tropical Medicine, Universidade de BrasíliaLaboratory of Epidemiology of Infectious and Parasitic Diseases, Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas GeraisAbstract Background This study presents the malaria burden in Brazil from 1990 to 2017 using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), by analyzing disease burden indicators in federated units of the Legal Amazon and Extra-Amazon regions, as well as describing malaria cases according to Plasmodium species occurring in the country. Methods We used estimates from the GBD 2017 to report years of life lost due to premature death (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) for malaria in Brazil, grouped by gender, age group, and Brazilian federated unit, from 1990 to 2017. Results are presented as absolute numbers and age-standardized rates (per 100,000 inhabitants) with 95% uncertainty intervals (UI). Results At the national level, the age-standardized DALYs rate due to malaria decreased by 92.0%, from 42.5 DALYs per 100,000 inhabitants (95% UI 16.6–56.9) in 1990 to 3.4 DALYs per 100,000 inhabitants (95% UI 2.7–4.7) in 2017. The YLLs were the main component of the total DALYs rate for malaria in 1990 (67.3%), and the YLDs were the main component of the metric in 2017 (61.8%). In 2017, the highest sex–age DALYs rate was found among females in the “< 1-year-old” age group, with a 6.4 DALYs per 100,000 inhabitants (95% UI 1.8–14.7) and among males in the age group of “20 to 24 years old”, with a 4.7 DALYs per 100,000 inhabitants (95% UI 3.3–9.9). Within the Brazilian Amazon region, the three federated units with the highest age-standardized DALYs rates in 2017 were Acre [28.4 (95% UI 14.2–39.1)], Roraima [28.3 (95% UI 13.5–40.2)], and Rondônia [24.7 (95% UI 11.4–34.8)]. Concerning the parasite species that caused malaria, 73.5% of the total of cases registered in the period had Plasmodium vivax as the etiological agent. Conclusions The results of the GBD 2017 show that despite the considerable reduction in the DALYs rates between 1990 and 2017, malaria remains a relevant and preventable disease, which in recent years has generated more years of life lost due to disability than deaths. The states endemic for malaria in the Amazon region require constant evaluation of preventive and control measures. The present study will contribute to the direction of current health policies aimed at reducing the burden of malaria in Brazil, as knowing the geographical and temporal distribution of the risk of death and disability of this disease can facilitate the planning, implementation, and improvement of control strategies aimed at eliminating the disease.http://link.springer.com/article/10.1186/s12963-020-00211-6MalariaBurden of diseaseDisability-adjusted life yearBrazil |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juliana Maria Trindade Bezerra David Soeiro Barbosa Francisco Rogerlândio Martins-Melo Guilherme Loureiro Werneck Érika Martins Braga Pedro Luiz Tauil Mariângela Carneiro |
spellingShingle |
Juliana Maria Trindade Bezerra David Soeiro Barbosa Francisco Rogerlândio Martins-Melo Guilherme Loureiro Werneck Érika Martins Braga Pedro Luiz Tauil Mariângela Carneiro Changes in malaria patterns in Brazil over 28 years (1990–2017): results from the Global Burden of Disease Study 2017 Population Health Metrics Malaria Burden of disease Disability-adjusted life year Brazil |
author_facet |
Juliana Maria Trindade Bezerra David Soeiro Barbosa Francisco Rogerlândio Martins-Melo Guilherme Loureiro Werneck Érika Martins Braga Pedro Luiz Tauil Mariângela Carneiro |
author_sort |
Juliana Maria Trindade Bezerra |
title |
Changes in malaria patterns in Brazil over 28 years (1990–2017): results from the Global Burden of Disease Study 2017 |
title_short |
Changes in malaria patterns in Brazil over 28 years (1990–2017): results from the Global Burden of Disease Study 2017 |
title_full |
Changes in malaria patterns in Brazil over 28 years (1990–2017): results from the Global Burden of Disease Study 2017 |
title_fullStr |
Changes in malaria patterns in Brazil over 28 years (1990–2017): results from the Global Burden of Disease Study 2017 |
title_full_unstemmed |
Changes in malaria patterns in Brazil over 28 years (1990–2017): results from the Global Burden of Disease Study 2017 |
title_sort |
changes in malaria patterns in brazil over 28 years (1990–2017): results from the global burden of disease study 2017 |
publisher |
BMC |
series |
Population Health Metrics |
issn |
1478-7954 |
publishDate |
2020-09-01 |
description |
Abstract Background This study presents the malaria burden in Brazil from 1990 to 2017 using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), by analyzing disease burden indicators in federated units of the Legal Amazon and Extra-Amazon regions, as well as describing malaria cases according to Plasmodium species occurring in the country. Methods We used estimates from the GBD 2017 to report years of life lost due to premature death (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) for malaria in Brazil, grouped by gender, age group, and Brazilian federated unit, from 1990 to 2017. Results are presented as absolute numbers and age-standardized rates (per 100,000 inhabitants) with 95% uncertainty intervals (UI). Results At the national level, the age-standardized DALYs rate due to malaria decreased by 92.0%, from 42.5 DALYs per 100,000 inhabitants (95% UI 16.6–56.9) in 1990 to 3.4 DALYs per 100,000 inhabitants (95% UI 2.7–4.7) in 2017. The YLLs were the main component of the total DALYs rate for malaria in 1990 (67.3%), and the YLDs were the main component of the metric in 2017 (61.8%). In 2017, the highest sex–age DALYs rate was found among females in the “< 1-year-old” age group, with a 6.4 DALYs per 100,000 inhabitants (95% UI 1.8–14.7) and among males in the age group of “20 to 24 years old”, with a 4.7 DALYs per 100,000 inhabitants (95% UI 3.3–9.9). Within the Brazilian Amazon region, the three federated units with the highest age-standardized DALYs rates in 2017 were Acre [28.4 (95% UI 14.2–39.1)], Roraima [28.3 (95% UI 13.5–40.2)], and Rondônia [24.7 (95% UI 11.4–34.8)]. Concerning the parasite species that caused malaria, 73.5% of the total of cases registered in the period had Plasmodium vivax as the etiological agent. Conclusions The results of the GBD 2017 show that despite the considerable reduction in the DALYs rates between 1990 and 2017, malaria remains a relevant and preventable disease, which in recent years has generated more years of life lost due to disability than deaths. The states endemic for malaria in the Amazon region require constant evaluation of preventive and control measures. The present study will contribute to the direction of current health policies aimed at reducing the burden of malaria in Brazil, as knowing the geographical and temporal distribution of the risk of death and disability of this disease can facilitate the planning, implementation, and improvement of control strategies aimed at eliminating the disease. |
topic |
Malaria Burden of disease Disability-adjusted life year Brazil |
url |
http://link.springer.com/article/10.1186/s12963-020-00211-6 |
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