Discovery of Matrinic Thiadiazole Derivatives as a Novel Family of Anti-Liver Fibrosis Agents via Repression of the TGFβ/Smad Pathway
A series of novel matrinic thiadiazole derivatives were designed, synthesized and evaluated for their inhibitory effect on COL1A1 promotor. The SAR indicated that: (i) the introduction of a thiadiazole on the 11-side chain was beneficial for activity; (ii) a 12-N-benzyl moiety was favorable for acti...
Main Authors: | Tianyu Niu, Weixiao Niu, Yunyang Bao, Ting Liu, Danqing Song, Yinghong Li, Hongwei He |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-07-01
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Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/23/7/1644 |
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