Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus
Background. Although retinol-binding protein 4 (RBP4) associates with insulin resistance and remnant-like particles triglyceride (RLP-TG) elevated in the insulin resistant state, few data exist regarding the relationship between RBP4 and RLP-TG. Subjects and Methods. The study included 92 Japanese t...
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doaj-5a5d9af8fd85411083b39e59a88eaf052020-11-25T00:48:58ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/143515143515Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes MellitusNaoto Yamaaki0Kunimasa Yagi1Junji Kobayashi2Atsushi Nohara3Naoko Ito4Akimichi Asano5Kaoru Nakano6Jianhui Liu7Takuya Okamoto8Yukiko Mori9Azusa Ohbatake10Satoko Okazaki11Yoshiyu Takeda12Masakazu Yamagishi13Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of General Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku 920-0293, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanDepartment of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, JapanBackground. Although retinol-binding protein 4 (RBP4) associates with insulin resistance and remnant-like particles triglyceride (RLP-TG) elevated in the insulin resistant state, few data exist regarding the relationship between RBP4 and RLP-TG. Subjects and Methods. The study included 92 Japanese type 2 diabetic mellitus (T2DM) male patients (age years, body mass index (BMI) kg/m2, waist circumference (WC) cm, and HbA1c (NGSP) %). Patients on medications affecting insulin sensitivity, including fibrates, biguanides, and thiazolidinedione, were excluded. Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by computed tomography. Results. RBP4 levels showed a significant positive correlation with RLP-TG ( and ), TG ( and ), RLP-TG/TG ( and ), and age ( and ), although there was no significant correlation with VFA, SFA, adiponectin levels, or homeostasis model of assessment insulin resistance (HOMA-R). Multiple regression analysis revealed that RBP4 was an independent determinant of RLP-TG () but was not a determinant of TG. Conclusions. RBP4 correlates positively with serum RLP-TG independent of fat accumulation in T2DM. RBP4 may regulate remnant metabolism independent of glycemic control in T2DM.http://dx.doi.org/10.1155/2013/143515 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Naoto Yamaaki Kunimasa Yagi Junji Kobayashi Atsushi Nohara Naoko Ito Akimichi Asano Kaoru Nakano Jianhui Liu Takuya Okamoto Yukiko Mori Azusa Ohbatake Satoko Okazaki Yoshiyu Takeda Masakazu Yamagishi |
spellingShingle |
Naoto Yamaaki Kunimasa Yagi Junji Kobayashi Atsushi Nohara Naoko Ito Akimichi Asano Kaoru Nakano Jianhui Liu Takuya Okamoto Yukiko Mori Azusa Ohbatake Satoko Okazaki Yoshiyu Takeda Masakazu Yamagishi Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus Journal of Diabetes Research |
author_facet |
Naoto Yamaaki Kunimasa Yagi Junji Kobayashi Atsushi Nohara Naoko Ito Akimichi Asano Kaoru Nakano Jianhui Liu Takuya Okamoto Yukiko Mori Azusa Ohbatake Satoko Okazaki Yoshiyu Takeda Masakazu Yamagishi |
author_sort |
Naoto Yamaaki |
title |
Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus |
title_short |
Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus |
title_full |
Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus |
title_fullStr |
Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus |
title_full_unstemmed |
Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus |
title_sort |
impact of serum retinol-binding protein 4 levels on regulation of remnant-like particles triglyceride in type 2 diabetes mellitus |
publisher |
Hindawi Limited |
series |
Journal of Diabetes Research |
issn |
2314-6745 2314-6753 |
publishDate |
2013-01-01 |
description |
Background. Although retinol-binding protein 4 (RBP4) associates with insulin resistance and remnant-like particles triglyceride (RLP-TG) elevated in the insulin resistant state, few data exist regarding the relationship between RBP4 and RLP-TG. Subjects and Methods. The study included 92 Japanese type 2 diabetic mellitus (T2DM) male patients (age years, body mass index (BMI) kg/m2, waist circumference (WC) cm, and HbA1c (NGSP) %). Patients on medications affecting insulin sensitivity, including fibrates, biguanides, and thiazolidinedione, were excluded. Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by computed tomography. Results. RBP4 levels showed a significant positive correlation with RLP-TG ( and ), TG ( and ), RLP-TG/TG ( and ), and age ( and ), although there was no significant correlation with VFA, SFA, adiponectin levels, or homeostasis model of assessment insulin resistance (HOMA-R). Multiple regression analysis revealed that RBP4 was an independent determinant of RLP-TG () but was not a determinant of TG. Conclusions. RBP4 correlates positively with serum RLP-TG independent of fat accumulation in T2DM. RBP4 may regulate remnant metabolism independent of glycemic control in T2DM. |
url |
http://dx.doi.org/10.1155/2013/143515 |
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