The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis
Carnosine is a natural occurring endogenous dipeptide that was proposed as an anti-aging agent more than 20 years ago. Carnosine can be found at low millimolar concentrations at brain level and different preclinical studies have demonstrated its antioxidant, anti-inflammatory, and anti-aggregation a...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-03-01
|
Series: | Biomedicines |
Subjects: | |
Online Access: | https://www.mdpi.com/2227-9059/9/3/253 |
id |
doaj-5a61cf959cd4470eaffb5c5124aa2d0d |
---|---|
record_format |
Article |
spelling |
doaj-5a61cf959cd4470eaffb5c5124aa2d0d2021-03-05T00:03:56ZengMDPI AGBiomedicines2227-90592021-03-01925325310.3390/biomedicines9030253The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-AnalysisGiuseppe Caruso0Justyna Godos1Sabrina Castellano2Agnieszka Micek3Paolo Murabito4Fabio Galvano5Raffaele Ferri6Giuseppe Grosso7Filippo Caraci8Department of Drug and Health Sciences, University of Catania, 95125 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyDepartment of Educational Sciences, University of Catania, 95124 Catania, ItalyDepartment of Nursing Management and Epidemiology Nursing, Faculty of Health Sciences, Jagiellonian University Medical College, 31-501 Krakow, PolandDepartment of General Surgery and Medical-Surgical Specialties, Section of Anesthesia and Intensive Care, University of Catania, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyOasi Research Institute—IRCCS, 94018 Troina, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyDepartment of Drug and Health Sciences, University of Catania, 95125 Catania, ItalyCarnosine is a natural occurring endogenous dipeptide that was proposed as an anti-aging agent more than 20 years ago. Carnosine can be found at low millimolar concentrations at brain level and different preclinical studies have demonstrated its antioxidant, anti-inflammatory, and anti-aggregation activity with neuroprotective effects in animal models of Alzheimer’s disease (AD). A selective deficit of carnosine has also been linked to cognitive decline in AD. Different clinical studies have been conducted to evaluate the impact of carnosine supplementation against cognitive decline in elderly and AD subjects. We conducted a systematic review with meta-analysis, in accordance with the PRISMA guidelines coupled to the PICOS approach, to investigate the therapeutic potential of carnosine against cognitive decline and depressive symptoms in elderly subjects. We found five studies matching the selection criteria. Carnosine/anserine was administered for 12 weeks at a dose of 1 g/day and improved global cognitive function, whereas no effects were detected on depressive symptoms. These data suggest a preliminary evidence of clinical efficacy of carnosine against cognitive decline both in elderly subjects and mild cognitive impairment (MCI) patients, although larger and long-term clinical studies are needed in MCI patients (with or without depression) to confirm the therapeutic potential of carnosine.https://www.mdpi.com/2227-9059/9/3/253carnosinecognitive functiondepressive symptomsage-related cognitive declineAlzheimer’s diseaseneuroinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giuseppe Caruso Justyna Godos Sabrina Castellano Agnieszka Micek Paolo Murabito Fabio Galvano Raffaele Ferri Giuseppe Grosso Filippo Caraci |
spellingShingle |
Giuseppe Caruso Justyna Godos Sabrina Castellano Agnieszka Micek Paolo Murabito Fabio Galvano Raffaele Ferri Giuseppe Grosso Filippo Caraci The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis Biomedicines carnosine cognitive function depressive symptoms age-related cognitive decline Alzheimer’s disease neuroinflammation |
author_facet |
Giuseppe Caruso Justyna Godos Sabrina Castellano Agnieszka Micek Paolo Murabito Fabio Galvano Raffaele Ferri Giuseppe Grosso Filippo Caraci |
author_sort |
Giuseppe Caruso |
title |
The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis |
title_short |
The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis |
title_full |
The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis |
title_fullStr |
The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis |
title_full_unstemmed |
The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis |
title_sort |
therapeutic potential of carnosine/anserine supplementation against cognitive decline: a systematic review with meta-analysis |
publisher |
MDPI AG |
series |
Biomedicines |
issn |
2227-9059 |
publishDate |
2021-03-01 |
description |
Carnosine is a natural occurring endogenous dipeptide that was proposed as an anti-aging agent more than 20 years ago. Carnosine can be found at low millimolar concentrations at brain level and different preclinical studies have demonstrated its antioxidant, anti-inflammatory, and anti-aggregation activity with neuroprotective effects in animal models of Alzheimer’s disease (AD). A selective deficit of carnosine has also been linked to cognitive decline in AD. Different clinical studies have been conducted to evaluate the impact of carnosine supplementation against cognitive decline in elderly and AD subjects. We conducted a systematic review with meta-analysis, in accordance with the PRISMA guidelines coupled to the PICOS approach, to investigate the therapeutic potential of carnosine against cognitive decline and depressive symptoms in elderly subjects. We found five studies matching the selection criteria. Carnosine/anserine was administered for 12 weeks at a dose of 1 g/day and improved global cognitive function, whereas no effects were detected on depressive symptoms. These data suggest a preliminary evidence of clinical efficacy of carnosine against cognitive decline both in elderly subjects and mild cognitive impairment (MCI) patients, although larger and long-term clinical studies are needed in MCI patients (with or without depression) to confirm the therapeutic potential of carnosine. |
topic |
carnosine cognitive function depressive symptoms age-related cognitive decline Alzheimer’s disease neuroinflammation |
url |
https://www.mdpi.com/2227-9059/9/3/253 |
work_keys_str_mv |
AT giuseppecaruso thetherapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT justynagodos thetherapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT sabrinacastellano thetherapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT agnieszkamicek thetherapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT paolomurabito thetherapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT fabiogalvano thetherapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT raffaeleferri thetherapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT giuseppegrosso thetherapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT filippocaraci thetherapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT giuseppecaruso therapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT justynagodos therapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT sabrinacastellano therapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT agnieszkamicek therapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT paolomurabito therapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT fabiogalvano therapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT raffaeleferri therapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT giuseppegrosso therapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis AT filippocaraci therapeuticpotentialofcarnosineanserinesupplementationagainstcognitivedeclineasystematicreviewwithmetaanalysis |
_version_ |
1724231350157836288 |