Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological Features
Background: To investigate the expressions of fibrinogen (Fib) and Interleukin-12 (IL-12) in serum of neonatal necrotizing enterocolitis (NEC), and to analyze the correlation between the two and their relationship with clinicopathological features. Methods: Forty two children with NEC treated in...
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Tehran University of Medical Sciences
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doaj-5a669b5a8f0f42c9b136fc99eb6c9dfe2021-01-02T15:42:25ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932020-07-0149810.18502/ijph.v49i8.3874Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological FeaturesYiyu YIN0Xiaole WU1Huaxin ZOU2Shixian LI3Zhenfang QIN4Tengfei ZHANG5Junhua CAO6Department of General Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. ChinaDepartment of Anesthesiology, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. ChinaDepartment of General Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. ChinaDepartment of General Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. ChinaDepartment of General Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. ChinaDepartment of General Surgery, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. ChinaDepartment of Emergency Medicine, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou 221006, P.R. China Background: To investigate the expressions of fibrinogen (Fib) and Interleukin-12 (IL-12) in serum of neonatal necrotizing enterocolitis (NEC), and to analyze the correlation between the two and their relationship with clinicopathological features. Methods: Forty two children with NEC treated in Xuzhou Children’s Hospital, Xuzhou Medical University Xuzhou, China from 2016-2019 were selected as an observation group and 40 children who underwent physical examination at the same period as a control group. The expression levels of Fib and IL-12 in the serum of two groups were detected by ELISA. The correlation between Fib and IL-12 in the observation group and the correlation among the expressions of Fib, IL-12, the clinicopathological features and common examination indexes of the children with NEC were investigated by Pearson correlation analysis. Results: The levels of Fib and IL-12 in the serum of the children in observation group were significantly higher than those in the control group were (P<0.05). There was a significant positive correlation between the levels of Fib and IL-12 in the serum of the children in observation group (P<0.05). The expression levels of Fib, IL-12 were not significantly correlated with sex and age of NEC children, but correlated with vomiting, diarrhea, bloody stool and bradycardia in NEC children (P<0.05). Fib and IL-12 were positively correlated with erythrocyte level (P<0.05) and negatively correlated with platelet level. Conclusion: The expressions of Fib and IL-12 in the serum of NEC children can objectively predict the severity of NEC. https://ijph.tums.ac.ir/index.php/ijph/article/view/20013Interleukin-12;Neonatal necrotizing enterocolitis;Clinicopathological features;Erythrocyte;Platelet |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiyu YIN Xiaole WU Huaxin ZOU Shixian LI Zhenfang QIN Tengfei ZHANG Junhua CAO |
spellingShingle |
Yiyu YIN Xiaole WU Huaxin ZOU Shixian LI Zhenfang QIN Tengfei ZHANG Junhua CAO Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological Features Iranian Journal of Public Health Interleukin-12; Neonatal necrotizing enterocolitis; Clinicopathological features; Erythrocyte; Platelet |
author_facet |
Yiyu YIN Xiaole WU Huaxin ZOU Shixian LI Zhenfang QIN Tengfei ZHANG Junhua CAO |
author_sort |
Yiyu YIN |
title |
Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological Features |
title_short |
Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological Features |
title_full |
Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological Features |
title_fullStr |
Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological Features |
title_full_unstemmed |
Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological Features |
title_sort |
expressions of fib, il-12 in serum of neonatal necrotizing enterocolitis and their correlation with clinicopathological features |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Public Health |
issn |
2251-6085 2251-6093 |
publishDate |
2020-07-01 |
description |
Background: To investigate the expressions of fibrinogen (Fib) and Interleukin-12 (IL-12) in serum of neonatal necrotizing enterocolitis (NEC), and to analyze the correlation between the two and their relationship with clinicopathological features.
Methods: Forty two children with NEC treated in Xuzhou Children’s Hospital, Xuzhou Medical University Xuzhou, China from 2016-2019 were selected as an observation group and 40 children who underwent physical examination at the same period as a control group. The expression levels of Fib and IL-12 in the serum of two groups were detected by ELISA. The correlation between Fib and IL-12 in the observation group and the correlation among the expressions of Fib, IL-12, the clinicopathological features and common examination indexes of the children with NEC were investigated by Pearson correlation analysis.
Results: The levels of Fib and IL-12 in the serum of the children in observation group were significantly higher than those in the control group were (P<0.05). There was a significant positive correlation between the levels of Fib and IL-12 in the serum of the children in observation group (P<0.05). The expression levels of Fib, IL-12 were not significantly correlated with sex and age of NEC children, but correlated with vomiting, diarrhea, bloody stool and bradycardia in NEC children (P<0.05). Fib and IL-12 were positively correlated with erythrocyte level (P<0.05) and negatively correlated with platelet level.
Conclusion: The expressions of Fib and IL-12 in the serum of NEC children can objectively predict the severity of NEC.
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topic |
Interleukin-12; Neonatal necrotizing enterocolitis; Clinicopathological features; Erythrocyte; Platelet |
url |
https://ijph.tums.ac.ir/index.php/ijph/article/view/20013 |
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