INTERACTION OF BIOMATERIALS CONTAINING CALCIUM HYDROXYAPATITE/ POLY-L-LACTIDE WITH THE SIMULATED BODY FLUID
The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as...
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doaj-5a67bff6950343509468010993fce2492020-11-24T21:41:02ZengUniversity in Nis, Faculty of MedicineActa Medica Medianae0365-44780182-12792011-12-015043539INTERACTION OF BIOMATERIALS CONTAINING CALCIUM HYDROXYAPATITE/ POLY-L-LACTIDE WITH THE SIMULATED BODY FLUIDMarija PetkovićPerica VasiljevićDragan UskokovićNenad IgnjatovićJelena ŽivkovićMiroslav MiljkovićŽarko MitićMarija VukelićJelena Živanov-ČurlisStevo NajmanThe purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersive X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery.http://publisher.medfak.ni.ac.rs/2011-html/4-broj/Marija%20Vukelic-Interaction.pdfbiomaterialsHAp/PLLASBFSEMED |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marija Petković Perica Vasiljević Dragan Uskoković Nenad Ignjatović Jelena Živković Miroslav Miljković Žarko Mitić Marija Vukelić Jelena Živanov-Čurlis Stevo Najman |
spellingShingle |
Marija Petković Perica Vasiljević Dragan Uskoković Nenad Ignjatović Jelena Živković Miroslav Miljković Žarko Mitić Marija Vukelić Jelena Živanov-Čurlis Stevo Najman INTERACTION OF BIOMATERIALS CONTAINING CALCIUM HYDROXYAPATITE/ POLY-L-LACTIDE WITH THE SIMULATED BODY FLUID Acta Medica Medianae biomaterials HAp/PLLA SBF SEM ED |
author_facet |
Marija Petković Perica Vasiljević Dragan Uskoković Nenad Ignjatović Jelena Živković Miroslav Miljković Žarko Mitić Marija Vukelić Jelena Živanov-Čurlis Stevo Najman |
author_sort |
Marija Petković |
title |
INTERACTION OF BIOMATERIALS CONTAINING CALCIUM HYDROXYAPATITE/ POLY-L-LACTIDE WITH THE SIMULATED BODY FLUID |
title_short |
INTERACTION OF BIOMATERIALS CONTAINING CALCIUM HYDROXYAPATITE/ POLY-L-LACTIDE WITH THE SIMULATED BODY FLUID |
title_full |
INTERACTION OF BIOMATERIALS CONTAINING CALCIUM HYDROXYAPATITE/ POLY-L-LACTIDE WITH THE SIMULATED BODY FLUID |
title_fullStr |
INTERACTION OF BIOMATERIALS CONTAINING CALCIUM HYDROXYAPATITE/ POLY-L-LACTIDE WITH THE SIMULATED BODY FLUID |
title_full_unstemmed |
INTERACTION OF BIOMATERIALS CONTAINING CALCIUM HYDROXYAPATITE/ POLY-L-LACTIDE WITH THE SIMULATED BODY FLUID |
title_sort |
interaction of biomaterials containing calcium hydroxyapatite/ poly-l-lactide with the simulated body fluid |
publisher |
University in Nis, Faculty of Medicine |
series |
Acta Medica Medianae |
issn |
0365-4478 0182-1279 |
publishDate |
2011-12-01 |
description |
The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersive X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery. |
topic |
biomaterials HAp/PLLA SBF SEM ED |
url |
http://publisher.medfak.ni.ac.rs/2011-html/4-broj/Marija%20Vukelic-Interaction.pdf |
work_keys_str_mv |
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