Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation

In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuplo...

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Main Authors:	Mira N. Moufarrej, Ronald J. Wong, Gary M. Shaw, David K. Stevenson, Stephen R. Quake
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-12-01
Series:	Frontiers in Pediatrics
Subjects:	transcriptome cell-free RNA preeclampsia prediction preterm birth IUGR
Online Access:	https://www.frontiersin.org/articles/10.3389/fped.2020.605219/full

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spelling	doaj-5a6ffa0f887a43aeb43ff51ef3862cfc2021-04-09T15:13:09ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-12-01810.3389/fped.2020.605219605219Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During GestationMira N. Moufarrej0Ronald J. Wong1Gary M. Shaw2David K. Stevenson3Stephen R. Quake4Departments of Bioengineering and Applied Physics, Stanford University, and Chan Zuckerberg Biohub, Stanford, CA, United StatesDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, United StatesDepartments of Bioengineering and Applied Physics, Stanford University, and Chan Zuckerberg Biohub, Stanford, CA, United StatesIn recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RNA levels can correspond with tissue-specific gene expression and provide a snapshot of prenatal health across gestation. Here, we review the physiologic origins of cfRNA and its novel applications and corresponding challenges to monitor fetal and maternal health and predict pregnancy-related complications.https://www.frontiersin.org/articles/10.3389/fped.2020.605219/fulltranscriptomecell-free RNApreeclampsiapredictionpreterm birthIUGR
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mira N. Moufarrej Ronald J. Wong Gary M. Shaw David K. Stevenson Stephen R. Quake
spellingShingle	Mira N. Moufarrej Ronald J. Wong Gary M. Shaw David K. Stevenson Stephen R. Quake Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation Frontiers in Pediatrics transcriptome cell-free RNA preeclampsia prediction preterm birth IUGR
author_facet	Mira N. Moufarrej Ronald J. Wong Gary M. Shaw David K. Stevenson Stephen R. Quake
author_sort	Mira N. Moufarrej
title	Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title_short	Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title_full	Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title_fullStr	Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title_full_unstemmed	Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation
title_sort	investigating pregnancy and its complications using circulating cell-free rna in women's blood during gestation
publisher	Frontiers Media S.A.
series	Frontiers in Pediatrics
issn	2296-2360
publishDate	2020-12-01
description	In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RNA levels can correspond with tissue-specific gene expression and provide a snapshot of prenatal health across gestation. Here, we review the physiologic origins of cfRNA and its novel applications and corresponding challenges to monitor fetal and maternal health and predict pregnancy-related complications.
topic	transcriptome cell-free RNA preeclampsia prediction preterm birth IUGR
url	https://www.frontiersin.org/articles/10.3389/fped.2020.605219/full
work_keys_str_mv	AT miranmoufarrej investigatingpregnancyanditscomplicationsusingcirculatingcellfreernainwomensbloodduringgestation AT ronaldjwong investigatingpregnancyanditscomplicationsusingcirculatingcellfreernainwomensbloodduringgestation AT garymshaw investigatingpregnancyanditscomplicationsusingcirculatingcellfreernainwomensbloodduringgestation AT davidkstevenson investigatingpregnancyanditscomplicationsusingcirculatingcellfreernainwomensbloodduringgestation AT stephenrquake investigatingpregnancyanditscomplicationsusingcirculatingcellfreernainwomensbloodduringgestation
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Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation

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