Recent advances in the molecular epidemiology of clinical malaria [version 1; referees: 4 approved]
Human malaria is a complex disease that can show a wide array of clinical outcomes, from asymptomatic carriage and chronic infection to acute disease presenting various life-threatening pathologies. The specific outcome of an infection is believed to be determined by a multifactorial interplay betwe...
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doaj-5a7a47a4c7064138b8190b3f0f9535a32020-11-25T03:35:24ZengF1000 Research LtdF1000Research2046-14022018-07-01710.12688/f1000research.14991.116320Recent advances in the molecular epidemiology of clinical malaria [version 1; referees: 4 approved]Mario Recker0Peter C Bull1Caroline O Buckee2Centre for Mathematics and the Environment, University of Exeter, Penryn Campus, Penryn, TR10 9FE, UKDepartment of Pathology, University of Cambridge, Cambridge, CB2 1QP, UKCenter for Communicable Disease Dynamics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USAHuman malaria is a complex disease that can show a wide array of clinical outcomes, from asymptomatic carriage and chronic infection to acute disease presenting various life-threatening pathologies. The specific outcome of an infection is believed to be determined by a multifactorial interplay between the host and the parasite but with a general trend toward disease attenuation with increasing prior exposure. Therefore, the main burden of malaria in a population can be understood as a function of transmission intensity, which itself is intricately linked to the prevalence of infected hosts and mosquito vectors, the distribution of infection outcomes, and the parasite population diversity. Predicting the long-term impact of malaria intervention measures therefore requires an in-depth understanding of how the parasite causes disease, how this relates to previous exposures, and how different infection pathologies contribute to parasite transmission. Here, we provide a brief overview of recent advances in the molecular epidemiology of clinical malaria and how these might prove to be influential in our fight against this important disease.https://f1000research.com/articles/7-1159/v1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mario Recker Peter C Bull Caroline O Buckee |
spellingShingle |
Mario Recker Peter C Bull Caroline O Buckee Recent advances in the molecular epidemiology of clinical malaria [version 1; referees: 4 approved] F1000Research |
author_facet |
Mario Recker Peter C Bull Caroline O Buckee |
author_sort |
Mario Recker |
title |
Recent advances in the molecular epidemiology of clinical malaria [version 1; referees: 4 approved] |
title_short |
Recent advances in the molecular epidemiology of clinical malaria [version 1; referees: 4 approved] |
title_full |
Recent advances in the molecular epidemiology of clinical malaria [version 1; referees: 4 approved] |
title_fullStr |
Recent advances in the molecular epidemiology of clinical malaria [version 1; referees: 4 approved] |
title_full_unstemmed |
Recent advances in the molecular epidemiology of clinical malaria [version 1; referees: 4 approved] |
title_sort |
recent advances in the molecular epidemiology of clinical malaria [version 1; referees: 4 approved] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2018-07-01 |
description |
Human malaria is a complex disease that can show a wide array of clinical outcomes, from asymptomatic carriage and chronic infection to acute disease presenting various life-threatening pathologies. The specific outcome of an infection is believed to be determined by a multifactorial interplay between the host and the parasite but with a general trend toward disease attenuation with increasing prior exposure. Therefore, the main burden of malaria in a population can be understood as a function of transmission intensity, which itself is intricately linked to the prevalence of infected hosts and mosquito vectors, the distribution of infection outcomes, and the parasite population diversity. Predicting the long-term impact of malaria intervention measures therefore requires an in-depth understanding of how the parasite causes disease, how this relates to previous exposures, and how different infection pathologies contribute to parasite transmission. Here, we provide a brief overview of recent advances in the molecular epidemiology of clinical malaria and how these might prove to be influential in our fight against this important disease. |
url |
https://f1000research.com/articles/7-1159/v1 |
work_keys_str_mv |
AT mariorecker recentadvancesinthemolecularepidemiologyofclinicalmalariaversion1referees4approved AT petercbull recentadvancesinthemolecularepidemiologyofclinicalmalariaversion1referees4approved AT carolineobuckee recentadvancesinthemolecularepidemiologyofclinicalmalariaversion1referees4approved |
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