Single-photon emission computed tomography/computed tomography imaging of RAGE in smoking-induced lung injury

Single-photon emission computed tomography/computed tomography imaging of RAGE in smoking-induced lung injury

Abstract Background Expression of the Receptor for Advanced Glycation Endproducts (RAGE) initiates pro-inflammatory pathways resulting in lung destruction. We hypothesized that RAGE directed imaging demonstrates increased lung uptake in smoke-exposure. Methods After exposure to room air or to cigare...

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Bibliographic Details
Main Authors: Monica P. Goldklang, Yared Tekabe, Tina Zelonina, Jordis Trischler, Rui Xiao, Kyle Stearns, Krissy Rodriguez, Alexander Shields, Alexander Romanov, Jeanine M. D’Armiento, Lynne L. Johnson
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Respiratory Research
Subjects:
Emphysema
Cigarette smoke
Rabbit
Damage-associated molecular pattern
Imaging
Receptor for advanced glycation end products
Online Access:http://link.springer.com/article/10.1186/s12931-019-1064-4

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