Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju
Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and -7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and ar...
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doaj-5a81330f3f95467eb98d5c9ae3ae8b2c2021-09-05T13:59:54ZengSciendoProceedings of the Latvian Academy of Sciences. Section B, Natural Sciences1407-009X2016-08-0170420521010.1515/prolas-2016-0032prolas-2016-0032Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar FibromialīijuČapenko Svetlana0Mihailova Marija1Rasa Santa2Krūmiņa Angelika3Zazerska Zane4Logina Ināra5Murovska Modra6Augusts Kirhenšteins Institute of Microbiology and Virology, Rīga Stradiņš University, Rātsupītes iela 5, Rīga, LV-1067, LATVIADepartment of Neurology and Neurosurgery, Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1007, LATVIAAugusts Kirhenšteins Institute of Microbiology and Virology, Rīga Stradiņš University, Rātsupītes iela 5, Rīga, LV-1067, LATVIADepatment of Infectology and Dermatology, Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1007, LATVIAAugusts Kirhenšteins Institute of Microbiology and Virology, Rīga Stradiņš University, Rātsupītes iela 5, Rīga, LV-1067, LATVIADepartment of Neurology and Neurosurgery, Rīga Stradiņš University, Dzirciema iela 16, Rīga, LV-1007, LATVIAAugusts Kirhenšteins Institute of Microbiology and Virology, Rīga Stradiņš University, Rātsupītes iela 5, Rīga, LV-1067, LATVIAFibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and -7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses potentially pathogenic to the nervous system. Presence of anti-HHV-6 and -HHV-7 antibodies and viral genomic sequences, viral loads, HHV-6 variant-specificity, and TNF-α level were studied in 41 FM patients and 50 healthy individuals using polymerase chain reactions, restriction endonuclease analysis and ELISA. There was no difference in the presence of anti-HHV-6 and anti-HHV-7 IgG class antibodies between FM patients and control group individuals. Viral sequences were found in 80.5% of FM patients and in 62.0% of controls. Significantly higher rate of concurrent HHV-6 and HHV-7 infection and higher viral loads in peripheral blood were detected in FM patients compared to the control group individuals. Plasma viremia was detected only in FM patients. Significantly higher TNF-α levels were detected in virus positive FM patients. From all positive cases only in two FM patients HHV-6A was revealed. Significantly higher detection frequency of concurrent HHV-6 and HHV-7 infection, simultaneous HHV-6 and HHV-7 activation, higher viral loads and TNF-α expression levels in primary FM patients than in control group individuals indicate the potential involvement of Roseoloviruses in development of this disorder.https://doi.org/10.1515/prolas-2016-0032fibromyalgiahuman herpesvirus-6human herpesvirus-7infectionmolecular diagnostic |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Čapenko Svetlana Mihailova Marija Rasa Santa Krūmiņa Angelika Zazerska Zane Logina Ināra Murovska Modra |
spellingShingle |
Čapenko Svetlana Mihailova Marija Rasa Santa Krūmiņa Angelika Zazerska Zane Logina Ināra Murovska Modra Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences fibromyalgia human herpesvirus-6 human herpesvirus-7 infection molecular diagnostic |
author_facet |
Čapenko Svetlana Mihailova Marija Rasa Santa Krūmiņa Angelika Zazerska Zane Logina Ināra Murovska Modra |
author_sort |
Čapenko Svetlana |
title |
Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju |
title_short |
Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju |
title_full |
Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju |
title_fullStr |
Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju |
title_full_unstemmed |
Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju |
title_sort |
possible relation of roseolovirus infection with fibromyalgia / iespējamā roseolovīrusu infekcijas saistība ar fibromialīiju |
publisher |
Sciendo |
series |
Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences |
issn |
1407-009X |
publishDate |
2016-08-01 |
description |
Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and -7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses potentially pathogenic to the nervous system. Presence of anti-HHV-6 and -HHV-7 antibodies and viral genomic sequences, viral loads, HHV-6 variant-specificity, and TNF-α level were studied in 41 FM patients and 50 healthy individuals using polymerase chain reactions, restriction endonuclease analysis and ELISA. There was no difference in the presence of anti-HHV-6 and anti-HHV-7 IgG class antibodies between FM patients and control group individuals. Viral sequences were found in 80.5% of FM patients and in 62.0% of controls. Significantly higher rate of concurrent HHV-6 and HHV-7 infection and higher viral loads in peripheral blood were detected in FM patients compared to the control group individuals. Plasma viremia was detected only in FM patients. Significantly higher TNF-α levels were detected in virus positive FM patients. From all positive cases only in two FM patients HHV-6A was revealed. Significantly higher detection frequency of concurrent HHV-6 and HHV-7 infection, simultaneous HHV-6 and HHV-7 activation, higher viral loads and TNF-α expression levels in primary FM patients than in control group individuals indicate the potential involvement of Roseoloviruses in development of this disorder. |
topic |
fibromyalgia human herpesvirus-6 human herpesvirus-7 infection molecular diagnostic |
url |
https://doi.org/10.1515/prolas-2016-0032 |
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