Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus?
Context: Impact of gestational diabetes mellitus (GDM) on the coagulation system, dynamics involved at a pathophysiological level and the exact mechanism remain unclear. Aims: To evaluate the association between diabetes-related parameters and hemostatic factors to search for a tendency o...
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doaj-5a8b0db82af24d1fa37efc6370c869f22020-11-25T03:13:16ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262016-07-0180210110510.4103/0974-2727.180790Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus?Suheyla Gorar0Bulent Alioglu1Esranur Ademoglu2Seyit Uyar3Handan Bekdemir4Zehra Candan5Beylan Saglam6Gonul Koc7Cavit Culha8Yalcin Aral9Department of Endocrinology and Metabolism, Antalya Training and Research Hospital, Antalya, TurkeyDepartment of Pediatric Hematology, Director of Hematology Laboratories, Ankara Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, TurkeyDepartment of Internal Medicine, Antalya Training and Research Hospital, Antalya, TurkeyDepartment of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, TurkeyDepartment of Pediatric Hematology, Hematology Laboratories, Ankara Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, TurkeyContext: Impact of gestational diabetes mellitus (GDM) on the coagulation system, dynamics involved at a pathophysiological level and the exact mechanism remain unclear. Aims: To evaluate the association between diabetes-related parameters and hemostatic factors to search for a tendency of thrombosis in GDM. Settings and Design: Nineteen pregnant women who had GDM, 16 healthy pregnant and 13 healthy nonpregnant controls admitted to the Endocrinology outpatient clinics were enrolled in the study. Subjects and Methods: Fasting and postprandial glucose, hemoglobin A1c and insulin levels, and insulin resistance; fructosamine, thrombin activatable fibrinolysis inhibitor (TAFI), tissue factor pathway inhibitor (TFPI), plasminogen activator inhibitor Type-1 (PAI-1), tissue-type plasminogen activator (t-PA), fibrinogen, plasminogen and hemoglobin levels, platelet counts, prothrombin time (PT), and activated partial thromboplastin time (aPTT) were studied. Statistical Analysis Used: One-way analysis of variance, Kruskal–Wallis, and post hoc Tukey honestly significant difference or Conover’s nonparametric multiple comparison tests for comparison of the study groups. Results: PT and aPTT were significantly lower in GDM patients compared to controls (P < 0.05), whereas fibrinogen and plasminogen levels were significantly higher in this group compared to both nonpregnant and healthy pregnant controls (P < 0.05 for each). TAFI, TFPI, PAI-1, and tissue t-PA levels were not significantly different among groups. Conclusions: Our findings indicate tendency to develop thrombosis in GDM similar to diabetes mellitus; but more comprehensive studies with larger sample size are needed to determine the relationship between GDM and hemostasis.http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.180790gestational diabetes mellitushemostatic factorsthrombosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suheyla Gorar Bulent Alioglu Esranur Ademoglu Seyit Uyar Handan Bekdemir Zehra Candan Beylan Saglam Gonul Koc Cavit Culha Yalcin Aral |
spellingShingle |
Suheyla Gorar Bulent Alioglu Esranur Ademoglu Seyit Uyar Handan Bekdemir Zehra Candan Beylan Saglam Gonul Koc Cavit Culha Yalcin Aral Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus? Journal of Laboratory Physicians gestational diabetes mellitus hemostatic factors thrombosis |
author_facet |
Suheyla Gorar Bulent Alioglu Esranur Ademoglu Seyit Uyar Handan Bekdemir Zehra Candan Beylan Saglam Gonul Koc Cavit Culha Yalcin Aral |
author_sort |
Suheyla Gorar |
title |
Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus? |
title_short |
Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus? |
title_full |
Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus? |
title_fullStr |
Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus? |
title_full_unstemmed |
Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus? |
title_sort |
is there a tendency for thrombosis in gestational diabetes mellitus? |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
Journal of Laboratory Physicians |
issn |
0974-2727 0974-7826 |
publishDate |
2016-07-01 |
description |
Context: Impact of gestational diabetes mellitus (GDM) on the coagulation system, dynamics involved at a pathophysiological level and the exact mechanism remain unclear.
Aims: To evaluate the association between diabetes-related parameters and hemostatic factors to search for a tendency of thrombosis in GDM.
Settings and Design: Nineteen pregnant women who had GDM, 16 healthy pregnant and 13 healthy nonpregnant controls admitted to the Endocrinology outpatient clinics were enrolled in the study.
Subjects and Methods: Fasting and postprandial glucose, hemoglobin A1c and insulin levels, and insulin resistance; fructosamine, thrombin activatable fibrinolysis inhibitor (TAFI), tissue factor pathway inhibitor (TFPI), plasminogen activator inhibitor Type-1 (PAI-1), tissue-type plasminogen activator (t-PA), fibrinogen, plasminogen and hemoglobin levels, platelet counts, prothrombin time (PT), and activated partial thromboplastin time (aPTT) were studied.
Statistical Analysis Used: One-way analysis of variance, Kruskal–Wallis, and post hoc Tukey honestly significant difference or Conover’s nonparametric multiple comparison tests for comparison of the study groups.
Results: PT and aPTT were significantly lower in GDM patients compared to controls (P < 0.05), whereas fibrinogen and plasminogen levels were significantly higher in this group compared to both nonpregnant and healthy pregnant controls (P < 0.05 for each). TAFI, TFPI, PAI-1, and tissue t-PA levels were not significantly different among groups.
Conclusions: Our findings indicate tendency to develop thrombosis in GDM similar to diabetes mellitus; but more comprehensive studies with larger sample size are needed to determine the relationship between GDM and hemostasis. |
topic |
gestational diabetes mellitus hemostatic factors thrombosis |
url |
http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.180790 |
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