Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice
The consumption of a high-fat diet can cause metabolic syndrome and induces host gut microbial dysbiosis and non-alcoholic fatty liver disease (NAFLD). We evaluated the effect of polyphenol-rich jaboticaba peel and seed powder (JPSP) on the gut microbial community composition and liver health in a m...
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Format: | Article |
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Elsevier
2021-12-01
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Series: | Biomedicine & Pharmacotherapy |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332221010982 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elaine Soares Aruanna C. Soares Patricia Leticia Trindade Elisa B. Monteiro Fabiane F. Martins Andrew J. Forgie Kim O.P. Inada Graziele F. de Bem Angela Resende Daniel Perrone Vanessa Souza-Mello Francisco Tomás-Barberán Benjamin P. Willing Mariana Monteiro Julio B. Daleprane |
spellingShingle |
Elaine Soares Aruanna C. Soares Patricia Leticia Trindade Elisa B. Monteiro Fabiane F. Martins Andrew J. Forgie Kim O.P. Inada Graziele F. de Bem Angela Resende Daniel Perrone Vanessa Souza-Mello Francisco Tomás-Barberán Benjamin P. Willing Mariana Monteiro Julio B. Daleprane Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice Biomedicine & Pharmacotherapy Obesity Polyphenols Steatosis Nutrigenomics Metabolism Gut microbiota |
author_facet |
Elaine Soares Aruanna C. Soares Patricia Leticia Trindade Elisa B. Monteiro Fabiane F. Martins Andrew J. Forgie Kim O.P. Inada Graziele F. de Bem Angela Resende Daniel Perrone Vanessa Souza-Mello Francisco Tomás-Barberán Benjamin P. Willing Mariana Monteiro Julio B. Daleprane |
author_sort |
Elaine Soares |
title |
Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice |
title_short |
Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice |
title_full |
Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice |
title_fullStr |
Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice |
title_full_unstemmed |
Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice |
title_sort |
jaboticaba (myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2021-12-01 |
description |
The consumption of a high-fat diet can cause metabolic syndrome and induces host gut microbial dysbiosis and non-alcoholic fatty liver disease (NAFLD). We evaluated the effect of polyphenol-rich jaboticaba peel and seed powder (JPSP) on the gut microbial community composition and liver health in a mouse model of NAFLD. Three-month-old C57BL/6 J male mice, received either a control (C, 10% of lipids as energy, n = 16) or high-fat (HF, 50% of lipids as energy, n = 64) diet for nine weeks. The HF mice were randomly subdivided into four groups (n = 16 in each group), three of which (HF-J5, HF-J10, and HF-J15) were supplemented with dietary JPSP for four weeks (5%, 10%, and 15%, respectively). In addition to attenuating weight gain, JPSP consumption improved dyslipidemia and insulin resistance. In a dose-dependent manner, JPSP consumption ameliorated the expression of hepatic lipogenesis genes (AMPK, SREBP-1, HGMCoA, and ABCG8). The effects on the microbial community structure were determined in all JPSP-supplemented groups; however, the HF-J10 and HF-J15 diets led to a drastic depletion in the species of numerous bacterial families (Bifidobacteriaceae, Mogibacteriaceae, Christensenellaceae, Clostridiaceae, Dehalobacteriaceae, Peptococcaceae, Peptostreptococcaceae, and Ruminococcaceae) compared to the HF diet, some of which represented a reversal of increases associated with HF. The Lachnospiraceae and Enterobacteriaceae families and the Parabacteroides, Sutterella, Allobaculum, and Akkermansia genera were enriched more in the HF-J10 and HF-J15 groups than in the HF group. In conclusion, JPSP consumption improved obesity-related metabolic profiles and had a strong impact on the microbial community structure, thereby reversing NAFLD and decreasing its severity. |
topic |
Obesity Polyphenols Steatosis Nutrigenomics Metabolism Gut microbiota |
url |
http://www.sciencedirect.com/science/article/pii/S0753332221010982 |
work_keys_str_mv |
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doaj-5ab00f7fd3eb467e800e5dd1438d8be52021-10-09T04:36:49ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-12-01144112314Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed miceElaine Soares0Aruanna C. Soares1Patricia Leticia Trindade2Elisa B. Monteiro3Fabiane F. Martins4Andrew J. Forgie5Kim O.P. Inada6Graziele F. de Bem7Angela Resende8Daniel Perrone9Vanessa Souza-Mello10Francisco Tomás-Barberán11Benjamin P. Willing12Mariana Monteiro13Julio B. Daleprane14Laboratory for studies of Interactions between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, BrazilLaboratory for studies of Interactions between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, BrazilLaboratory for studies of Interactions between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, BrazilLaboratory for studies of Interactions between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, BrazilLaboratory of Morphometry, Metabolism, and Cardiovascular Disease, Biomedical Center, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, BrazilDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, CanadaLaboratory for studies of Interactions between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, BrazilLaboratory of Cardiovascular Pharmacology and Medicinal Plants, Department of Pharmacology, Rio de Janeiro State University, Rio de Janeiro, BrazilLaboratory of Cardiovascular Pharmacology and Medicinal Plants, Department of Pharmacology, Rio de Janeiro State University, Rio de Janeiro, BrazilLaboratório de Bioquímica Nutricional e de Alimentos, Chemistry Institute, Federal University of Rio de Janeiro, Av. Athos da Silveira Ramos 149, CT, Bloco A, sala 528 A, 21941-909 Rio de Janeiro, BrazilLaboratory of Morphometry, Metabolism, and Cardiovascular Disease, Biomedical Center, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, BrazilResearch Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Campus de Espinardo, Murcia, SpainDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, CanadaLaboratório de Alimentos Funcionais, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilLaboratory for studies of Interactions between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil; Correspondence to: Rio de Janeiro State University, Rua São Francisco Xavier, 524, Pavilhão João Lyra Filho, 12º andar, Sala 12.150 Bloco F, 20550-900 Rio de Janeiro, RJ, Brazil.The consumption of a high-fat diet can cause metabolic syndrome and induces host gut microbial dysbiosis and non-alcoholic fatty liver disease (NAFLD). We evaluated the effect of polyphenol-rich jaboticaba peel and seed powder (JPSP) on the gut microbial community composition and liver health in a mouse model of NAFLD. Three-month-old C57BL/6 J male mice, received either a control (C, 10% of lipids as energy, n = 16) or high-fat (HF, 50% of lipids as energy, n = 64) diet for nine weeks. The HF mice were randomly subdivided into four groups (n = 16 in each group), three of which (HF-J5, HF-J10, and HF-J15) were supplemented with dietary JPSP for four weeks (5%, 10%, and 15%, respectively). In addition to attenuating weight gain, JPSP consumption improved dyslipidemia and insulin resistance. In a dose-dependent manner, JPSP consumption ameliorated the expression of hepatic lipogenesis genes (AMPK, SREBP-1, HGMCoA, and ABCG8). The effects on the microbial community structure were determined in all JPSP-supplemented groups; however, the HF-J10 and HF-J15 diets led to a drastic depletion in the species of numerous bacterial families (Bifidobacteriaceae, Mogibacteriaceae, Christensenellaceae, Clostridiaceae, Dehalobacteriaceae, Peptococcaceae, Peptostreptococcaceae, and Ruminococcaceae) compared to the HF diet, some of which represented a reversal of increases associated with HF. The Lachnospiraceae and Enterobacteriaceae families and the Parabacteroides, Sutterella, Allobaculum, and Akkermansia genera were enriched more in the HF-J10 and HF-J15 groups than in the HF group. In conclusion, JPSP consumption improved obesity-related metabolic profiles and had a strong impact on the microbial community structure, thereby reversing NAFLD and decreasing its severity.http://www.sciencedirect.com/science/article/pii/S0753332221010982ObesityPolyphenolsSteatosisNutrigenomicsMetabolismGut microbiota |