Emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cells
Abstract Cancer-testicular Antigens (CTAs) belong to a group of proteins that under normal conditions are strictly expressed in a male’s reproductive tissues. However, upon malignisation, they are frequently re-expressed in neoplastic tissues of various origin. A number of studies have shown that di...
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2021-05-01
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Series: | Cell Death Discovery |
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doaj-5abf278eda7d4f859a0852778cb6062c2021-05-09T11:44:28ZengNature Publishing GroupCell Death Discovery2058-77162021-05-01711910.1038/s41420-021-00482-4Emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cellsOleg Shuvalov0Alyona Kizenko1Alexey Petukhov2Olga Fedorova3Alexandra Daks4Nikolai Barlev5Institute of cytology RASInstitute of cytology RASInstitute of cytology RASInstitute of cytology RASInstitute of cytology RASInstitute of cytology RASAbstract Cancer-testicular Antigens (CTAs) belong to a group of proteins that under normal conditions are strictly expressed in a male’s reproductive tissues. However, upon malignisation, they are frequently re-expressed in neoplastic tissues of various origin. A number of studies have shown that different CTAs affect growth, migration and invasion of tumor cells and favor cancer development and metastasis. Two members of the CTA group, Semenogelin 1 and 2 (SEMG1 and SEMG2, or SEMGs) represent the major component of human seminal fluid. They regulate the motility and capacitation of sperm. They are often re-expressed in different malignancies including breast cancer. However, there is almost no information about the functional properties of SEMGs in cancer cells. In this review, we highlight the role of SEMGs in the reproductive system and also summarize the data on their expression and functions in malignant cells of various origins.https://doi.org/10.1038/s41420-021-00482-4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Oleg Shuvalov Alyona Kizenko Alexey Petukhov Olga Fedorova Alexandra Daks Nikolai Barlev |
spellingShingle |
Oleg Shuvalov Alyona Kizenko Alexey Petukhov Olga Fedorova Alexandra Daks Nikolai Barlev Emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cells Cell Death Discovery |
author_facet |
Oleg Shuvalov Alyona Kizenko Alexey Petukhov Olga Fedorova Alexandra Daks Nikolai Barlev |
author_sort |
Oleg Shuvalov |
title |
Emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cells |
title_short |
Emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cells |
title_full |
Emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cells |
title_fullStr |
Emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cells |
title_full_unstemmed |
Emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cells |
title_sort |
emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cells |
publisher |
Nature Publishing Group |
series |
Cell Death Discovery |
issn |
2058-7716 |
publishDate |
2021-05-01 |
description |
Abstract Cancer-testicular Antigens (CTAs) belong to a group of proteins that under normal conditions are strictly expressed in a male’s reproductive tissues. However, upon malignisation, they are frequently re-expressed in neoplastic tissues of various origin. A number of studies have shown that different CTAs affect growth, migration and invasion of tumor cells and favor cancer development and metastasis. Two members of the CTA group, Semenogelin 1 and 2 (SEMG1 and SEMG2, or SEMGs) represent the major component of human seminal fluid. They regulate the motility and capacitation of sperm. They are often re-expressed in different malignancies including breast cancer. However, there is almost no information about the functional properties of SEMGs in cancer cells. In this review, we highlight the role of SEMGs in the reproductive system and also summarize the data on their expression and functions in malignant cells of various origins. |
url |
https://doi.org/10.1038/s41420-021-00482-4 |
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