Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23
Interleukin-23 (IL-23) is essential for the differentiation of pathogenic effector T helper 17 (Th17) cells, but its role in memory Th17 cell responses is unclear. Using the experimental autoimmune encephalomyelitis (EAE) model, we report that memory Th17 cells rapidly expanded in response to recha...
Main Authors: | Christopher J. Haines, Yi Chen, Wendy M. Blumenschein, Renu Jain, Charlie Chang, Barbara Joyce-Shaikh, Katherine Porth, Katia Boniface, Jeanine Mattson, Beth Basham, Stephen M. Anderton, Terrill K. McClanahan, Svetlana Sadekova, Daniel J. Cua, Mandy J. McGeachy |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2013-05-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124713001599 |
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