A case study of choroideremia carrier – Use of multi-spectral imaging in highlighting clinical features
Purpose: To report the use of non-invasive multi-spectral imaging of a female choroideremia (CHM) carrier with mild visual symptoms and extensive fundus mottling. Observation: This was an observational case report study. A symptomatic 42-year-old female with a history of binocular CHM presented for...
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doaj-5acbaa1eb40343b69922ddd5fb4352982020-11-24T23:35:37ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362016-07-012C182210.1016/j.ajoc.2016.04.003A case study of choroideremia carrier – Use of multi-spectral imaging in highlighting clinical featuresPravin U. Dugel0Cheryl N. Zimmer1Ayda M. Shahidi2Retinal Consultants of Arizona, Phoenix, Arizona, USAAnnidis Corporation, Ottawa, CanadaAnnidis Corporation, Ottawa, CanadaPurpose: To report the use of non-invasive multi-spectral imaging of a female choroideremia (CHM) carrier with mild visual symptoms and extensive fundus mottling. Observation: This was an observational case report study. A symptomatic 42-year-old female with a history of binocular CHM presented for routine ocular examination and underwent review of her clinical and photographic records, optical coherence tomography (OCT), intravenous fluorescein angiography (IVFA) and multi-spectral imaging (MSI). Dilated fundus examination and photography revealed similar outcomes of diffuse mottling with normal looking vessels. IVFA showed large irregular and confluent patches of RPE atrophy in the peripapillary and parapapillary areas as well as the midperiphery, corresponding to the OCT findings. The entire range of MSI imaging (520–940 nm) clearly illustrated the anomalies of the fundus including retinal pigment epithelium (RPE) mottling with melanin clumping not readily seen with the other imaging modalities. MSI fundus autofluorescence (MSI-FAF) showed a spotty hypo and hyperautofluorescent appearance of the fundus, consistent with the observations seen on IVFA and OCT images. Conclusion and Importance: MSI significantly improves visualization of the retinal pigment epithelium in choroideremia. The non-invasive nature of MSI technique is a valuable tool in monitoring the effect of retinal and choroidal presentation in patients with CHM.http://www.sciencedirect.com/science/article/pii/S245199361530030XMulti-spectral imagingChoroideremiaRetinal imagingRetinal pigment epithelium |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pravin U. Dugel Cheryl N. Zimmer Ayda M. Shahidi |
spellingShingle |
Pravin U. Dugel Cheryl N. Zimmer Ayda M. Shahidi A case study of choroideremia carrier – Use of multi-spectral imaging in highlighting clinical features American Journal of Ophthalmology Case Reports Multi-spectral imaging Choroideremia Retinal imaging Retinal pigment epithelium |
author_facet |
Pravin U. Dugel Cheryl N. Zimmer Ayda M. Shahidi |
author_sort |
Pravin U. Dugel |
title |
A case study of choroideremia carrier – Use of multi-spectral imaging in highlighting clinical features |
title_short |
A case study of choroideremia carrier – Use of multi-spectral imaging in highlighting clinical features |
title_full |
A case study of choroideremia carrier – Use of multi-spectral imaging in highlighting clinical features |
title_fullStr |
A case study of choroideremia carrier – Use of multi-spectral imaging in highlighting clinical features |
title_full_unstemmed |
A case study of choroideremia carrier – Use of multi-spectral imaging in highlighting clinical features |
title_sort |
case study of choroideremia carrier – use of multi-spectral imaging in highlighting clinical features |
publisher |
Elsevier |
series |
American Journal of Ophthalmology Case Reports |
issn |
2451-9936 |
publishDate |
2016-07-01 |
description |
Purpose: To report the use of non-invasive multi-spectral imaging of a female choroideremia (CHM) carrier with mild visual symptoms and extensive fundus mottling.
Observation: This was an observational case report study. A symptomatic 42-year-old female with a history of binocular CHM presented for routine ocular examination and underwent review of her clinical and photographic records, optical coherence tomography (OCT), intravenous fluorescein angiography (IVFA) and multi-spectral imaging (MSI). Dilated fundus examination and photography revealed similar outcomes of diffuse mottling with normal looking vessels. IVFA showed large irregular and confluent patches of RPE atrophy in the peripapillary and parapapillary areas as well as the midperiphery, corresponding to the OCT findings. The entire range of MSI imaging (520–940 nm) clearly illustrated the anomalies of the fundus including retinal pigment epithelium (RPE) mottling with melanin clumping not readily seen with the other imaging modalities. MSI fundus autofluorescence (MSI-FAF) showed a spotty hypo and hyperautofluorescent appearance of the fundus, consistent with the observations seen on IVFA and OCT images.
Conclusion and Importance: MSI significantly improves visualization of the retinal pigment epithelium in choroideremia. The non-invasive nature of MSI technique is a valuable tool in monitoring the effect of retinal and choroidal presentation in patients with CHM. |
topic |
Multi-spectral imaging Choroideremia Retinal imaging Retinal pigment epithelium |
url |
http://www.sciencedirect.com/science/article/pii/S245199361530030X |
work_keys_str_mv |
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