Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages.
Hsp90s, members of the Heat Shock Protein class, protect the structure and function of proteins and play a significant task in cellular homeostasis and signal transduction. In order to determine the number of hsp90 gene copies and encoded proteins in fungal and animal lineages and through that key d...
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doaj-5ad96003d2944838833870f899ec297d2020-11-25T01:31:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7321710.1371/journal.pone.0073217Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages.Chrysoula N PantzartziElena DrosopoulouZacharias G ScourasHsp90s, members of the Heat Shock Protein class, protect the structure and function of proteins and play a significant task in cellular homeostasis and signal transduction. In order to determine the number of hsp90 gene copies and encoded proteins in fungal and animal lineages and through that key duplication events that this family has undergone, we collected and evaluated Hsp90 protein sequences and corresponding Expressed Sequence Tags and analyzed available genomes from various taxa. We provide evidence for duplication events affecting either single species or wider taxonomic groups. With regard to Fungi, duplicated genes have been detected in several lineages. In invertebrates, we demonstrate key duplication events in certain clades of Arthropoda and Mollusca, and a possible gene loss event in a hymenopteran family. Finally, we infer that the duplication event responsible for the two (a and b) isoforms in vertebrates occurred probably shortly after the split of Hyperoartia and Gnathostomata.http://europepmc.org/articles/PMC3774752?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chrysoula N Pantzartzi Elena Drosopoulou Zacharias G Scouras |
spellingShingle |
Chrysoula N Pantzartzi Elena Drosopoulou Zacharias G Scouras Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages. PLoS ONE |
author_facet |
Chrysoula N Pantzartzi Elena Drosopoulou Zacharias G Scouras |
author_sort |
Chrysoula N Pantzartzi |
title |
Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages. |
title_short |
Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages. |
title_full |
Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages. |
title_fullStr |
Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages. |
title_full_unstemmed |
Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages. |
title_sort |
assessment and reconstruction of novel hsp90 genes: duplications, gains and losses in fungal and animal lineages. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Hsp90s, members of the Heat Shock Protein class, protect the structure and function of proteins and play a significant task in cellular homeostasis and signal transduction. In order to determine the number of hsp90 gene copies and encoded proteins in fungal and animal lineages and through that key duplication events that this family has undergone, we collected and evaluated Hsp90 protein sequences and corresponding Expressed Sequence Tags and analyzed available genomes from various taxa. We provide evidence for duplication events affecting either single species or wider taxonomic groups. With regard to Fungi, duplicated genes have been detected in several lineages. In invertebrates, we demonstrate key duplication events in certain clades of Arthropoda and Mollusca, and a possible gene loss event in a hymenopteran family. Finally, we infer that the duplication event responsible for the two (a and b) isoforms in vertebrates occurred probably shortly after the split of Hyperoartia and Gnathostomata. |
url |
http://europepmc.org/articles/PMC3774752?pdf=render |
work_keys_str_mv |
AT chrysoulanpantzartzi assessmentandreconstructionofnovelhsp90genesduplicationsgainsandlossesinfungalandanimallineages AT elenadrosopoulou assessmentandreconstructionofnovelhsp90genesduplicationsgainsandlossesinfungalandanimallineages AT zachariasgscouras assessmentandreconstructionofnovelhsp90genesduplicationsgainsandlossesinfungalandanimallineages |
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