Phosphene thresholds correlate with paired-pulse suppression of visually evoked potentials
Background: Phosphene thresholds (PT) induced by transcranial magnetic stimulation (TMS) as well as paired-pulse suppression (PPS) of visually evoked potentials (VEP) are used to characterize visual cortex excitability, however, their relation remains unknown. Methods: We measured PT after single TM...
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doaj-5ae18029a89847d8b01d4485463c9b592021-03-18T04:35:47ZengElsevierBrain Stimulation1935-861X2013-03-0162118121Phosphene thresholds correlate with paired-pulse suppression of visually evoked potentialsOliver Höffken0Melanie Lenz1Matthias Sczesny-Kaiser2Hubert R. Dinse3Martin Tegenthoff4Department of Neurology, Ruhr-University Bochum, BG-Universitätsklinikum Bergmannsheil, Bochum, Germany; Corresponding author. Tel.: +49 234 3020; fax: +49 234 3026888.Department of Neurology, Ruhr-University Bochum, BG-Universitätsklinikum Bergmannsheil, Bochum, GermanyDepartment of Neurology, Ruhr-University Bochum, BG-Universitätsklinikum Bergmannsheil, Bochum, GermanyInstitut für Neuroinformatik, Neural Plasticity Lab, Ruhr-University Bochum, GermanyDepartment of Neurology, Ruhr-University Bochum, BG-Universitätsklinikum Bergmannsheil, Bochum, GermanyBackground: Phosphene thresholds (PT) induced by transcranial magnetic stimulation (TMS) as well as paired-pulse suppression (PPS) of visually evoked potentials (VEP) are used to characterize visual cortex excitability, however, their relation remains unknown. Methods: We measured PT after single TMS over the occipital lobe, and recorded VEPs after paired-pulse stimulation at short stimulus-onset-asynchronies in the same subject. PPS was expressed by the ratio second to first response. Results: We found a negative correlation between PT and PPS (r = −0.36, P = 0.039) indicating that higher PT were associated with smaller ratios indicative of low excitability, and vice versa. There was no difference in PPS between subjects who perceived phosphenes and those who did not. Conclusions: Although both approaches target different mechanisms, PT and PPS seem to reflect common characteristics of visual cortex excitability. The lack of differences in PPS in subjects not perceiving phosphenes suggests that they might not have higher excitability levels.http://www.sciencedirect.com/science/article/pii/S1935861X12000228Visual cortexExcitabilityPaired-pulse suppression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Oliver Höffken Melanie Lenz Matthias Sczesny-Kaiser Hubert R. Dinse Martin Tegenthoff |
spellingShingle |
Oliver Höffken Melanie Lenz Matthias Sczesny-Kaiser Hubert R. Dinse Martin Tegenthoff Phosphene thresholds correlate with paired-pulse suppression of visually evoked potentials Brain Stimulation Visual cortex Excitability Paired-pulse suppression |
author_facet |
Oliver Höffken Melanie Lenz Matthias Sczesny-Kaiser Hubert R. Dinse Martin Tegenthoff |
author_sort |
Oliver Höffken |
title |
Phosphene thresholds correlate with paired-pulse suppression of visually evoked potentials |
title_short |
Phosphene thresholds correlate with paired-pulse suppression of visually evoked potentials |
title_full |
Phosphene thresholds correlate with paired-pulse suppression of visually evoked potentials |
title_fullStr |
Phosphene thresholds correlate with paired-pulse suppression of visually evoked potentials |
title_full_unstemmed |
Phosphene thresholds correlate with paired-pulse suppression of visually evoked potentials |
title_sort |
phosphene thresholds correlate with paired-pulse suppression of visually evoked potentials |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2013-03-01 |
description |
Background: Phosphene thresholds (PT) induced by transcranial magnetic stimulation (TMS) as well as paired-pulse suppression (PPS) of visually evoked potentials (VEP) are used to characterize visual cortex excitability, however, their relation remains unknown. Methods: We measured PT after single TMS over the occipital lobe, and recorded VEPs after paired-pulse stimulation at short stimulus-onset-asynchronies in the same subject. PPS was expressed by the ratio second to first response. Results: We found a negative correlation between PT and PPS (r = −0.36, P = 0.039) indicating that higher PT were associated with smaller ratios indicative of low excitability, and vice versa. There was no difference in PPS between subjects who perceived phosphenes and those who did not. Conclusions: Although both approaches target different mechanisms, PT and PPS seem to reflect common characteristics of visual cortex excitability. The lack of differences in PPS in subjects not perceiving phosphenes suggests that they might not have higher excitability levels. |
topic |
Visual cortex Excitability Paired-pulse suppression |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X12000228 |
work_keys_str_mv |
AT oliverhoffken phosphenethresholdscorrelatewithpairedpulsesuppressionofvisuallyevokedpotentials AT melanielenz phosphenethresholdscorrelatewithpairedpulsesuppressionofvisuallyevokedpotentials AT matthiassczesnykaiser phosphenethresholdscorrelatewithpairedpulsesuppressionofvisuallyevokedpotentials AT hubertrdinse phosphenethresholdscorrelatewithpairedpulsesuppressionofvisuallyevokedpotentials AT martintegenthoff phosphenethresholdscorrelatewithpairedpulsesuppressionofvisuallyevokedpotentials |
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