Optimal mechanical properties of a scaffold for cartilage regeneration using finite element analysis
The development of successful scaffolds for bone tissue engineering requires concurrent engineering that combines different research fields. In previous studies, phenomenological computational models predicted the mechanical properties of a scaffold in a simple loading condition using the mechano-re...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2019-02-01
|
Series: | Journal of Tissue Engineering |
Online Access: | https://doi.org/10.1177/2041731419832133 |
id |
doaj-5ae74c07ea68495f92e724f35dca1928 |
---|---|
record_format |
Article |
spelling |
doaj-5ae74c07ea68495f92e724f35dca19282020-11-25T03:29:30ZengSAGE PublishingJournal of Tissue Engineering2041-73142019-02-011010.1177/2041731419832133Optimal mechanical properties of a scaffold for cartilage regeneration using finite element analysisYong-Gon Koh0Jin-Ah Lee1Yong Sang Kim2Hwa Yong Lee3Hyo Jeong Kim4Kyoung-Tak Kang5Joint Reconstruction Center, Department of Orthopaedic Surgery, Yonsei Sarang Hospital, Seoul, Republic of KoreaDepartment of Mechanical Engineering, Yonsei University, Seoul, Republic of KoreaJoint Reconstruction Center, Department of Orthopaedic Surgery, Yonsei Sarang Hospital, Seoul, Republic of KoreaDepartment of Mechanical Engineering, Yonsei University, Seoul, Republic of KoreaDepartment of Sport and Healthy Aging, Korea National Sport University, Seoul, Republic of KoreaDepartment of Mechanical Engineering, Yonsei University, Seoul, Republic of KoreaThe development of successful scaffolds for bone tissue engineering requires concurrent engineering that combines different research fields. In previous studies, phenomenological computational models predicted the mechanical properties of a scaffold in a simple loading condition using the mechano-regulation theory. Therefore, the aim of this study is to predict the mechanical properties of an optimum scaffold required for cartilage regeneration using three-dimensional knee joint developed from medical imaging and mechano-regulation theory. It was predicted that the scaffold with optimal mechanical properties would result in greater amounts of cartilage tissue formation than without a scaffold. The results demonstrated the ability of the algorithms to design optimized scaffolds with target properties and confirmed the applicability of set techniques for bone tissue engineering. The scaffolds were optimized to suit the site-specific loading requirements, and the results reveal a new approach for computational simulations in tissue engineering.https://doi.org/10.1177/2041731419832133 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong-Gon Koh Jin-Ah Lee Yong Sang Kim Hwa Yong Lee Hyo Jeong Kim Kyoung-Tak Kang |
spellingShingle |
Yong-Gon Koh Jin-Ah Lee Yong Sang Kim Hwa Yong Lee Hyo Jeong Kim Kyoung-Tak Kang Optimal mechanical properties of a scaffold for cartilage regeneration using finite element analysis Journal of Tissue Engineering |
author_facet |
Yong-Gon Koh Jin-Ah Lee Yong Sang Kim Hwa Yong Lee Hyo Jeong Kim Kyoung-Tak Kang |
author_sort |
Yong-Gon Koh |
title |
Optimal mechanical properties of a scaffold for cartilage regeneration using finite element analysis |
title_short |
Optimal mechanical properties of a scaffold for cartilage regeneration using finite element analysis |
title_full |
Optimal mechanical properties of a scaffold for cartilage regeneration using finite element analysis |
title_fullStr |
Optimal mechanical properties of a scaffold for cartilage regeneration using finite element analysis |
title_full_unstemmed |
Optimal mechanical properties of a scaffold for cartilage regeneration using finite element analysis |
title_sort |
optimal mechanical properties of a scaffold for cartilage regeneration using finite element analysis |
publisher |
SAGE Publishing |
series |
Journal of Tissue Engineering |
issn |
2041-7314 |
publishDate |
2019-02-01 |
description |
The development of successful scaffolds for bone tissue engineering requires concurrent engineering that combines different research fields. In previous studies, phenomenological computational models predicted the mechanical properties of a scaffold in a simple loading condition using the mechano-regulation theory. Therefore, the aim of this study is to predict the mechanical properties of an optimum scaffold required for cartilage regeneration using three-dimensional knee joint developed from medical imaging and mechano-regulation theory. It was predicted that the scaffold with optimal mechanical properties would result in greater amounts of cartilage tissue formation than without a scaffold. The results demonstrated the ability of the algorithms to design optimized scaffolds with target properties and confirmed the applicability of set techniques for bone tissue engineering. The scaffolds were optimized to suit the site-specific loading requirements, and the results reveal a new approach for computational simulations in tissue engineering. |
url |
https://doi.org/10.1177/2041731419832133 |
work_keys_str_mv |
AT yonggonkoh optimalmechanicalpropertiesofascaffoldforcartilageregenerationusingfiniteelementanalysis AT jinahlee optimalmechanicalpropertiesofascaffoldforcartilageregenerationusingfiniteelementanalysis AT yongsangkim optimalmechanicalpropertiesofascaffoldforcartilageregenerationusingfiniteelementanalysis AT hwayonglee optimalmechanicalpropertiesofascaffoldforcartilageregenerationusingfiniteelementanalysis AT hyojeongkim optimalmechanicalpropertiesofascaffoldforcartilageregenerationusingfiniteelementanalysis AT kyoungtakkang optimalmechanicalpropertiesofascaffoldforcartilageregenerationusingfiniteelementanalysis |
_version_ |
1724578801593090048 |