Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis
NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes are poorly understood. Through analysis of the NCOA4...
Main Authors: | Joseph D Mancias, Laura Pontano Vaites, Sahar Nissim, Douglas E Biancur, Andrew J Kim, Xiaoxu Wang, Yu Liu, Wolfram Goessling, Alec C Kimmelman, J Wade Harper |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/10308 |
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