Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy

Marwa Abdelshafy, Ahmed Abdelshafy Ophthalmology Department, Benha Faculty of Medicine, Benha University, Benha, EgyptCorrespondence: Marwa AbdelshafyOphthalmology Department, Benha Faculty of Medicine, Benha University, 1 El Amira Fawzya Street, Benha, Qalubiya Governorate 13512, EgyptEmail drmarwa...

Full description

Bibliographic Details
Main Authors: Abdelshafy M, Abdelshafy A
Format: Article
Language:English
Published: Dove Medical Press 2020-04-01
Series:Clinical Ophthalmology
Subjects:
Online Access:https://www.dovepress.com/correlations-between-optical-coherence-tomography-angiography-paramete-peer-reviewed-article-OPTH
id doaj-5afb73588cf146399bf4cdb784c3b38f
record_format Article
spelling doaj-5afb73588cf146399bf4cdb784c3b38f2020-11-25T02:10:32ZengDove Medical PressClinical Ophthalmology1177-54832020-04-01Volume 141107111553282Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic RetinopathyAbdelshafy MAbdelshafy AMarwa Abdelshafy, Ahmed Abdelshafy Ophthalmology Department, Benha Faculty of Medicine, Benha University, Benha, EgyptCorrespondence: Marwa AbdelshafyOphthalmology Department, Benha Faculty of Medicine, Benha University, 1 El Amira Fawzya Street, Benha, Qalubiya Governorate 13512, EgyptEmail drmarwatabl2012@gmail.comAim: The aim of this study was to assess the correlation between different optical coherence tomography angiography (OCTA) parameters and the best corrected visual acuity (BCVA) in patients with diabetic retinopathy (DR).Patients and Methods: Sixty eyes of 60 participants were included in this prospective study: 40 diabetic patients [20 with non-proliferative diabetic retinopathy (NPDR group), 20 with proliferative diabetic retinopathy (PDR group)] and 20 age- and gender-matched normal healthy subjects (control group). After full ophthalmological examination and fundus fluorescein angiography, OCTA was performed for all participants. Quantitative OCTA parameters, such as the foveal avascular zone (FAZ) area, the superficial capillary plexus vessel density (%) (SCP-VD) and the deep capillary plexus vessel density (%) (DCP-VD) in, whole and parafoveal areas were measured. Correlations between BCVA and OCTA parameters were analyzed.Results: There were no statistically significant differences between groups regarding age, gender, refraction, macular thickness or intraocular pressure. The median (IQR) FAZ area was 0.42 (0.39– 0.46) mm2 in the NPDR group, 0.54 (0.45– 0.65) mm2 in the PDR group and 0.24 (0.21– 0.26) mm2 in the control group (P< 0.001). The FAZ area increased with increasing severity of DR. SCP-VD and DCP-VD showed significant differences between groups (P< 0.001). Vessel density (VD) was decreased in both DCP and SCP as DR progressed. There was a significant positive correlation between BCVA (LogMAR) and FAZ area. There were significant negative correlations between BCVA (LogMAR) and VD in both SCP and DCP. Stepwise multiple linear regression analysis demonstrated that SCP-VD in the whole area and DCP-VD in the parafoveal area were the best predictive factors for BCVA in the NPDR and PDR groups.Conclusion: With progression of DR, the VD decreased and the FAZ area increased, and both parameters were correlated with poor visual acuity. OCTA is a non-invasive tool which can be used to detect diabetic macular ischemia and help in the prediction of visual prognosis.Keywords: visual acuity, OCT angiography, vessel density, foveal avascular zone, diabetic retinopathyhttps://www.dovepress.com/correlations-between-optical-coherence-tomography-angiography-paramete-peer-reviewed-article-OPTHvisual acuityoct-angiographyvessel densityfoveal avascular zonediabetic retinopathy.
collection DOAJ
language English
format Article
sources DOAJ
author Abdelshafy M
Abdelshafy A
spellingShingle Abdelshafy M
Abdelshafy A
Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
Clinical Ophthalmology
visual acuity
oct-angiography
vessel density
foveal avascular zone
diabetic retinopathy.
author_facet Abdelshafy M
Abdelshafy A
author_sort Abdelshafy M
title Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
title_short Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
title_full Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
title_fullStr Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
title_full_unstemmed Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
title_sort correlations between optical coherence tomography angiography parameters and the visual acuity in patients with diabetic retinopathy
publisher Dove Medical Press
series Clinical Ophthalmology
issn 1177-5483
publishDate 2020-04-01
description Marwa Abdelshafy, Ahmed Abdelshafy Ophthalmology Department, Benha Faculty of Medicine, Benha University, Benha, EgyptCorrespondence: Marwa AbdelshafyOphthalmology Department, Benha Faculty of Medicine, Benha University, 1 El Amira Fawzya Street, Benha, Qalubiya Governorate 13512, EgyptEmail drmarwatabl2012@gmail.comAim: The aim of this study was to assess the correlation between different optical coherence tomography angiography (OCTA) parameters and the best corrected visual acuity (BCVA) in patients with diabetic retinopathy (DR).Patients and Methods: Sixty eyes of 60 participants were included in this prospective study: 40 diabetic patients [20 with non-proliferative diabetic retinopathy (NPDR group), 20 with proliferative diabetic retinopathy (PDR group)] and 20 age- and gender-matched normal healthy subjects (control group). After full ophthalmological examination and fundus fluorescein angiography, OCTA was performed for all participants. Quantitative OCTA parameters, such as the foveal avascular zone (FAZ) area, the superficial capillary plexus vessel density (%) (SCP-VD) and the deep capillary plexus vessel density (%) (DCP-VD) in, whole and parafoveal areas were measured. Correlations between BCVA and OCTA parameters were analyzed.Results: There were no statistically significant differences between groups regarding age, gender, refraction, macular thickness or intraocular pressure. The median (IQR) FAZ area was 0.42 (0.39– 0.46) mm2 in the NPDR group, 0.54 (0.45– 0.65) mm2 in the PDR group and 0.24 (0.21– 0.26) mm2 in the control group (P< 0.001). The FAZ area increased with increasing severity of DR. SCP-VD and DCP-VD showed significant differences between groups (P< 0.001). Vessel density (VD) was decreased in both DCP and SCP as DR progressed. There was a significant positive correlation between BCVA (LogMAR) and FAZ area. There were significant negative correlations between BCVA (LogMAR) and VD in both SCP and DCP. Stepwise multiple linear regression analysis demonstrated that SCP-VD in the whole area and DCP-VD in the parafoveal area were the best predictive factors for BCVA in the NPDR and PDR groups.Conclusion: With progression of DR, the VD decreased and the FAZ area increased, and both parameters were correlated with poor visual acuity. OCTA is a non-invasive tool which can be used to detect diabetic macular ischemia and help in the prediction of visual prognosis.Keywords: visual acuity, OCT angiography, vessel density, foveal avascular zone, diabetic retinopathy
topic visual acuity
oct-angiography
vessel density
foveal avascular zone
diabetic retinopathy.
url https://www.dovepress.com/correlations-between-optical-coherence-tomography-angiography-paramete-peer-reviewed-article-OPTH
work_keys_str_mv AT abdelshafym correlationsbetweenopticalcoherencetomographyangiographyparametersandthevisualacuityinpatientswithdiabeticretinopathy
AT abdelshafya correlationsbetweenopticalcoherencetomographyangiographyparametersandthevisualacuityinpatientswithdiabeticretinopathy
_version_ 1724919172709744640