Role of eosinophils in protective immunity against secondary nematode infections
Infections with parasites, especially those involving nematodes that invade tissues, induce a strong Th2-type immune response, which increases immunoglobulin E and eosinophil levels in the blood and tissues. Eosinophils are not effective against all possible helminth infections, but are known to be...
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Online Access: | http://dx.doi.org/10.1080/25785826.2019.1697135 |
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doaj-5b04d743a60e49a195a245e3a24834e92020-11-25T02:26:26ZengTaylor & Francis GroupImmunological Medicine2578-58262019-10-0142414815510.1080/25785826.2019.16971351697135Role of eosinophils in protective immunity against secondary nematode infectionsKoubun Yasuda0Etsushi Kuroda1Hyogo College of MedicineHyogo College of MedicineInfections with parasites, especially those involving nematodes that invade tissues, induce a strong Th2-type immune response, which increases immunoglobulin E and eosinophil levels in the blood and tissues. Eosinophils are not effective against all possible helminth infections, but are known to be effective against nematode larvae. In particular, when a host is re-infected by a species of nematode that it previously encountered, the activation of acquired immunity causes robust accumulation and activation of eosinophils that damages the nematode larvae. Eosinophil production and activation processes are mainly induced by interleukin (IL)-5, which is produced by Th2 cells and group 2 innate lymphoid cells, and eosinophils have been shown to generally participate in host defense, inflammation, and immunomodulation. Recently, several papers have reported host defense by non-antigen-specific immune activation, in which group 2 innate lymphoid cells and Th2 cells produce interleukin (IL)-5 and IL-13 in response to IL-33 stimulation. This immune activation is produced by migrating larvae of a species that differs from the species previously encountered. Eosinophils also play an important role in the eradication of migrating larvae. Thus, eosinophils contribute to host defense in both antigen-specific and non-antigen-specific manners.http://dx.doi.org/10.1080/25785826.2019.1697135interleukin-33interleukin-5th2lungnon-antigen-specific |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Koubun Yasuda Etsushi Kuroda |
spellingShingle |
Koubun Yasuda Etsushi Kuroda Role of eosinophils in protective immunity against secondary nematode infections Immunological Medicine interleukin-33 interleukin-5 th2 lung non-antigen-specific |
author_facet |
Koubun Yasuda Etsushi Kuroda |
author_sort |
Koubun Yasuda |
title |
Role of eosinophils in protective immunity against secondary nematode infections |
title_short |
Role of eosinophils in protective immunity against secondary nematode infections |
title_full |
Role of eosinophils in protective immunity against secondary nematode infections |
title_fullStr |
Role of eosinophils in protective immunity against secondary nematode infections |
title_full_unstemmed |
Role of eosinophils in protective immunity against secondary nematode infections |
title_sort |
role of eosinophils in protective immunity against secondary nematode infections |
publisher |
Taylor & Francis Group |
series |
Immunological Medicine |
issn |
2578-5826 |
publishDate |
2019-10-01 |
description |
Infections with parasites, especially those involving nematodes that invade tissues, induce a strong Th2-type immune response, which increases immunoglobulin E and eosinophil levels in the blood and tissues. Eosinophils are not effective against all possible helminth infections, but are known to be effective against nematode larvae. In particular, when a host is re-infected by a species of nematode that it previously encountered, the activation of acquired immunity causes robust accumulation and activation of eosinophils that damages the nematode larvae. Eosinophil production and activation processes are mainly induced by interleukin (IL)-5, which is produced by Th2 cells and group 2 innate lymphoid cells, and eosinophils have been shown to generally participate in host defense, inflammation, and immunomodulation. Recently, several papers have reported host defense by non-antigen-specific immune activation, in which group 2 innate lymphoid cells and Th2 cells produce interleukin (IL)-5 and IL-13 in response to IL-33 stimulation. This immune activation is produced by migrating larvae of a species that differs from the species previously encountered. Eosinophils also play an important role in the eradication of migrating larvae. Thus, eosinophils contribute to host defense in both antigen-specific and non-antigen-specific manners. |
topic |
interleukin-33 interleukin-5 th2 lung non-antigen-specific |
url |
http://dx.doi.org/10.1080/25785826.2019.1697135 |
work_keys_str_mv |
AT koubunyasuda roleofeosinophilsinprotectiveimmunityagainstsecondarynematodeinfections AT etsushikuroda roleofeosinophilsinprotectiveimmunityagainstsecondarynematodeinfections |
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