Virus–Host Interactions in Foot-and-Mouth Disease Virus Infection
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which has been regarded as a persistent challenge for the livestock industry in many countries. Foot-and-mouth disease virus (FMDV) is the etiological agent of FMD that can spread rapidly by direct and indirect tra...
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doaj-5b080c53f65f4afb9cd415fc9d78191d2021-02-26T06:30:08ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011210.3389/fimmu.2021.571509571509Virus–Host Interactions in Foot-and-Mouth Disease Virus InfectionKangli LiCongcong WangFan YangWeijun CaoZixiang ZhuHaixue ZhengFoot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which has been regarded as a persistent challenge for the livestock industry in many countries. Foot-and-mouth disease virus (FMDV) is the etiological agent of FMD that can spread rapidly by direct and indirect transmission. FMDV is internalized into host cell by the interaction between FMDV capsid proteins and cellular receptors. When the virus invades into the cells, the host antiviral system is quickly activated to suppress the replication of the virus and remove the virus. To retain fitness and host adaptation, various viruses have evolved multiple elegant strategies to manipulate host machine and circumvent the host antiviral responses. Therefore, identification of virus-host interactions is critical for understanding the host defense against virus infections and the pathogenesis of the viral infectious diseases. This review elaborates on the virus-host interactions during FMDV infection to summarize the pathogenic mechanisms of FMD, and we hope it can provide insights for designing effective vaccines or drugs to prevent and control the spread of FMD and other diseases caused by picornaviruses.https://www.frontiersin.org/articles/10.3389/fimmu.2021.571509/fullFMDVinteractionsimmune dysfunctionpathogenesisviral infection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kangli Li Congcong Wang Fan Yang Weijun Cao Zixiang Zhu Haixue Zheng |
spellingShingle |
Kangli Li Congcong Wang Fan Yang Weijun Cao Zixiang Zhu Haixue Zheng Virus–Host Interactions in Foot-and-Mouth Disease Virus Infection Frontiers in Immunology FMDV interactions immune dysfunction pathogenesis viral infection |
author_facet |
Kangli Li Congcong Wang Fan Yang Weijun Cao Zixiang Zhu Haixue Zheng |
author_sort |
Kangli Li |
title |
Virus–Host Interactions in Foot-and-Mouth Disease Virus Infection |
title_short |
Virus–Host Interactions in Foot-and-Mouth Disease Virus Infection |
title_full |
Virus–Host Interactions in Foot-and-Mouth Disease Virus Infection |
title_fullStr |
Virus–Host Interactions in Foot-and-Mouth Disease Virus Infection |
title_full_unstemmed |
Virus–Host Interactions in Foot-and-Mouth Disease Virus Infection |
title_sort |
virus–host interactions in foot-and-mouth disease virus infection |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-02-01 |
description |
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which has been regarded as a persistent challenge for the livestock industry in many countries. Foot-and-mouth disease virus (FMDV) is the etiological agent of FMD that can spread rapidly by direct and indirect transmission. FMDV is internalized into host cell by the interaction between FMDV capsid proteins and cellular receptors. When the virus invades into the cells, the host antiviral system is quickly activated to suppress the replication of the virus and remove the virus. To retain fitness and host adaptation, various viruses have evolved multiple elegant strategies to manipulate host machine and circumvent the host antiviral responses. Therefore, identification of virus-host interactions is critical for understanding the host defense against virus infections and the pathogenesis of the viral infectious diseases. This review elaborates on the virus-host interactions during FMDV infection to summarize the pathogenic mechanisms of FMD, and we hope it can provide insights for designing effective vaccines or drugs to prevent and control the spread of FMD and other diseases caused by picornaviruses. |
topic |
FMDV interactions immune dysfunction pathogenesis viral infection |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.571509/full |
work_keys_str_mv |
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1724249933013319680 |