Mycological Aspects of Onychomycosis in Khuzestan Province, Iran, a New Scenario as Shift from Dermatophytes towards Yeasts
Abstract Background and Purpose: Onychomycosis is fungal infection of the nails with an overall increasing incidence, worldwide. The epidemiological aspects of onychomycosis in Khuzestan, Iran have not been established. This study was aimed to evaluate the clinical and mycological status of fungal n...
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Mazandaran University of Medical Sciences
2017-12-01
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doaj-5b0d6002e30c4d85ac3fdf87020ca7ea2020-11-24T23:15:10ZengMazandaran University of Medical SciencesCurrent Medical Mycology2423-34392423-34202017-12-01342631Mycological Aspects of Onychomycosis in Khuzestan Province, Iran, a New Scenario as Shift from Dermatophytes towards YeastsMahnaz fatahinia0Sima Jafarpour1Abdollah Rafiei2Simin Taghipour3Koichi Makimura4Ali Rezaei-Matehkolaei5 Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Department of Medical Parasitology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran Department of Medical Mycology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan. 5 General Medical Education and Research Center, Teikyo University, Tokyo, Japan Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Abstract Background and Purpose: Onychomycosis is fungal infection of the nails with an overall increasing incidence, worldwide. The epidemiological aspects of onychomycosis in Khuzestan, Iran have not been established. This study was aimed to evaluate the clinical and mycological status of fungal nail infection in Khuzestan Province, Iran. Material and Methods: The study population included 433 patients (143 males vs. 290 females). Nail samples were undergone to primary direct microscopy and culture. The isolated yeasts and dermatophytes were then subjected to additional molecular identification by r-DNA ITS-RFLP. Identification of some non-dermatophytes molds (NDMs) and unknown yeasts were accomplished by ITS and beta tubulin sequencing. Results: Onychomycosis was confirmed in 154 patients (35.6%; 58 males vs. 96 females) whose age ranged from 2-85 years with highest prevalence in the age group of 41-50 years old. Infection was more occurred due to yeasts (59.7%) with Candida albicans as the most frequent (29.35%) species, followed by C. parapsilosis (13.8%) and C. tropicalis (4.5%). Dermatophytes were isolated in 38.35% of the cases; the most commonly isolates were found to be Trichophyton interdigitale (21.1%), Epidermophyton floccosum (10.5%), T. rubrum (5.25%) and Microsporum canis (1.5%). NDMs were isolated only in 4.5% with Aspergillus spp., as the commonest agents. Dermatophytes and NDMs more frequently seen in toenails whereas, yeasts mostly infected fingernails and fingernail onychomycosis has remarkably more occurred in females than males (P < 0.05). Conclusion: The study highlighted that the agents of infection in the population with onychomycosis from Khuzestan have shifted from dermatophytes to the yeasts. http://cmm.mazums.ac.ir/browse.php?a_code=A-10-237-1&slc_lang=en&sid=1Keywords: Onychomycosis Khuzestan Yeast Deramatophyte NDM. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahnaz fatahinia Sima Jafarpour Abdollah Rafiei Simin Taghipour Koichi Makimura Ali Rezaei-Matehkolaei |
spellingShingle |
Mahnaz fatahinia Sima Jafarpour Abdollah Rafiei Simin Taghipour Koichi Makimura Ali Rezaei-Matehkolaei Mycological Aspects of Onychomycosis in Khuzestan Province, Iran, a New Scenario as Shift from Dermatophytes towards Yeasts Current Medical Mycology Keywords: Onychomycosis Khuzestan Yeast Deramatophyte NDM. |
author_facet |
Mahnaz fatahinia Sima Jafarpour Abdollah Rafiei Simin Taghipour Koichi Makimura Ali Rezaei-Matehkolaei |
author_sort |
Mahnaz fatahinia |
title |
Mycological Aspects of Onychomycosis in Khuzestan Province, Iran, a New Scenario as Shift from Dermatophytes towards Yeasts |
title_short |
Mycological Aspects of Onychomycosis in Khuzestan Province, Iran, a New Scenario as Shift from Dermatophytes towards Yeasts |
title_full |
Mycological Aspects of Onychomycosis in Khuzestan Province, Iran, a New Scenario as Shift from Dermatophytes towards Yeasts |
title_fullStr |
Mycological Aspects of Onychomycosis in Khuzestan Province, Iran, a New Scenario as Shift from Dermatophytes towards Yeasts |
title_full_unstemmed |
Mycological Aspects of Onychomycosis in Khuzestan Province, Iran, a New Scenario as Shift from Dermatophytes towards Yeasts |
title_sort |
mycological aspects of onychomycosis in khuzestan province, iran, a new scenario as shift from dermatophytes towards yeasts |
publisher |
Mazandaran University of Medical Sciences |
series |
Current Medical Mycology |
issn |
2423-3439 2423-3420 |
publishDate |
2017-12-01 |
description |
Abstract
Background and Purpose: Onychomycosis is fungal infection of the nails with an overall increasing incidence, worldwide. The epidemiological aspects of onychomycosis in Khuzestan, Iran have not been established. This study was aimed to evaluate the clinical and mycological status of fungal nail infection in Khuzestan Province, Iran.
Material and Methods: The study population included 433 patients (143 males vs. 290 females). Nail samples were undergone to primary direct microscopy and culture. The isolated yeasts and dermatophytes were then subjected to additional molecular identification by r-DNA ITS-RFLP. Identification of some non-dermatophytes molds (NDMs) and unknown yeasts were accomplished by ITS and beta tubulin sequencing.
Results: Onychomycosis was confirmed in 154 patients (35.6%; 58 males vs. 96 females) whose age ranged from 2-85 years with highest prevalence in the age group of 41-50 years old. Infection was more occurred due to yeasts (59.7%) with Candida albicans as the most frequent (29.35%) species, followed by C. parapsilosis (13.8%) and C. tropicalis (4.5%). Dermatophytes were isolated in 38.35% of the cases; the most commonly isolates were found to be Trichophyton interdigitale (21.1%), Epidermophyton floccosum (10.5%), T. rubrum (5.25%) and Microsporum canis (1.5%). NDMs were isolated only in 4.5% with Aspergillus spp., as the commonest agents. Dermatophytes and NDMs more frequently seen in toenails whereas, yeasts mostly infected fingernails and fingernail onychomycosis has remarkably more occurred in females than males (P < 0.05).
Conclusion: The study highlighted that the agents of infection in the population with onychomycosis from Khuzestan have shifted from dermatophytes to the yeasts.
|
topic |
Keywords: Onychomycosis Khuzestan Yeast Deramatophyte NDM. |
url |
http://cmm.mazums.ac.ir/browse.php?a_code=A-10-237-1&slc_lang=en&sid=1 |
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